Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells

Joana Carrelha, Yiran Meng, Laura M. Kettyle, Tiago C. Luis, Ruggiero Norfo, Verónica Alcolea, Hanane Boukarabila, Francesca Grasso, Adriana Gambardella, Amit Grover, Kari Högstrand, Allegra M. Lord, Alejandra Sanjuan-Pla, Petter S. Woll, Claus Nerlov () and Sten Eirik W. Jacobsen ()
Additional contact information
Joana Carrelha: Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Yiran Meng: Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Laura M. Kettyle: Wallenberg Institute for Regenerative Medicine, Karolinska Institutet
Tiago C. Luis: Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Ruggiero Norfo: Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Verónica Alcolea: Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Hanane Boukarabila: Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Francesca Grasso: Karolinska Institutet, Center for Hematology and Regenerative Medicine, Karolinska Institutet
Adriana Gambardella: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Amit Grover: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Kari Högstrand: Wallenberg Institute for Regenerative Medicine, Karolinska Institutet
Allegra M. Lord: Wallenberg Institute for Regenerative Medicine, Karolinska Institutet
Alejandra Sanjuan-Pla: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Petter S. Woll: Karolinska Institutet, Center for Hematology and Regenerative Medicine, Karolinska Institutet
Claus Nerlov: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Sten Eirik W. Jacobsen: Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford

Nature, 2018, vol. 554, issue 7690, 106-111

Abstract: Analysis of transplantation of single haematopoietic stem cells in mice defines stable lineage-restricted fates in long-term self-renewing multipotent stem cells, including a class of multipotent stem cells that exclusively replenishes the megakaryocyte/platelet lineage.

Date: 2018
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DOI: 10.1038/nature25455

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