Mitochondrial translation requires folate-dependent tRNA methylation

Raphael J. Morscher, Gregory S. Ducker, Sophia Hsin-Jung Li, Johannes A. Mayer, Zemer Gitai, Wolfgang Sperl and Joshua D. Rabinowitz ()
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Raphael J. Morscher: Lewis-Sigler Institute for Integrative Genomics, Princeton University
Gregory S. Ducker: Lewis-Sigler Institute for Integrative Genomics, Princeton University
Sophia Hsin-Jung Li: Princeton University
Johannes A. Mayer: Salzburger Landeskliniken and Paracelsus Medical University
Zemer Gitai: Princeton University
Wolfgang Sperl: Salzburger Landeskliniken and Paracelsus Medical University
Joshua D. Rabinowitz: Lewis-Sigler Institute for Integrative Genomics, Princeton University

Nature, 2018, vol. 554, issue 7690, 128-132

Abstract: Mammalian mitochondria use folate-bound one-carbon units generated by the enzyme SHMT2 to methylate tRNA, and this modification is required for mitochondrial translation and thus oxidative phosphorylation.

Date: 2018
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DOI: 10.1038/nature25460

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