The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms

Markus Alexander Grohme, Siegfried Schloissnig (), Andrei Rozanski, Martin Pippel, George Robert Young, Sylke Winkler, Holger Brandl, Ian Henry, Andreas Dahl, Sean Powell, Michael Hiller, Eugene Myers () and Jochen Christian Rink ()
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Markus Alexander Grohme: Max Planck Institute of Molecular Cell Biology and Genetics
Siegfried Schloissnig: Heidelberg Institute for Theoretical Studies
Andrei Rozanski: Max Planck Institute of Molecular Cell Biology and Genetics
Martin Pippel: Heidelberg Institute for Theoretical Studies
George Robert Young: The Francis Crick Institute
Sylke Winkler: Max Planck Institute of Molecular Cell Biology and Genetics
Holger Brandl: Max Planck Institute of Molecular Cell Biology and Genetics
Ian Henry: Max Planck Institute of Molecular Cell Biology and Genetics
Andreas Dahl: Deep Sequencing Group, BIOTEC/Center for Regenerative Therapies Dresden, Cluster of Excellence at TU Dresden
Sean Powell: Heidelberg Institute for Theoretical Studies
Michael Hiller: Max Planck Institute of Molecular Cell Biology and Genetics
Eugene Myers: Max Planck Institute of Molecular Cell Biology and Genetics
Jochen Christian Rink: Max Planck Institute of Molecular Cell Biology and Genetics

Nature, 2018, vol. 554, issue 7690, 56-61

Abstract: Abstract The planarian Schmidtea mediterranea is an important model for stem cell research and regeneration, but adequate genome resources for this species have been lacking. Here we report a highly contiguous genome assembly of S. mediterranea, using long-read sequencing and a de novo assembler (MARVEL) enhanced for low-complexity reads. The S. mediterranea genome is highly polymorphic and repetitive, and harbours a novel class of giant retroelements. Furthermore, the genome assembly lacks a number of highly conserved genes, including critical components of the mitotic spindle assembly checkpoint, but planarians maintain checkpoint function. Our genome assembly provides a key model system resource that will be useful for studying regeneration and the evolutionary plasticity of core cell biological mechanisms.

Date: 2018
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DOI: 10.1038/nature25473

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