Enhancer redundancy provides phenotypic robustness in mammalian development

Marco Osterwalder, Iros Barozzi, Virginie Tissières, Yoko Fukuda-Yuzawa, Brandon J. Mannion, Sarah Y. Afzal, Elizabeth A. Lee, Yiwen Zhu, Ingrid Plajzer-Frick, Catherine S. Pickle, Momoe Kato, Tyler H. Garvin, Quan T. Pham, Anne N. Harrington, Jennifer A. Akiyama, Veena Afzal, Javier Lopez-Rios, Diane E. Dickel (), Axel Visel () and Len A. Pennacchio ()
Additional contact information
Marco Osterwalder: Environmental Genomics and Systems Biology Division
Iros Barozzi: Environmental Genomics and Systems Biology Division
Virginie Tissières: University of Basel
Yoko Fukuda-Yuzawa: Environmental Genomics and Systems Biology Division
Brandon J. Mannion: Environmental Genomics and Systems Biology Division
Sarah Y. Afzal: Environmental Genomics and Systems Biology Division
Elizabeth A. Lee: Environmental Genomics and Systems Biology Division
Yiwen Zhu: Environmental Genomics and Systems Biology Division
Ingrid Plajzer-Frick: Environmental Genomics and Systems Biology Division
Catherine S. Pickle: Environmental Genomics and Systems Biology Division
Momoe Kato: Environmental Genomics and Systems Biology Division
Tyler H. Garvin: Environmental Genomics and Systems Biology Division
Quan T. Pham: Environmental Genomics and Systems Biology Division
Anne N. Harrington: Environmental Genomics and Systems Biology Division
Jennifer A. Akiyama: Environmental Genomics and Systems Biology Division
Veena Afzal: Environmental Genomics and Systems Biology Division
Javier Lopez-Rios: University of Basel
Diane E. Dickel: Environmental Genomics and Systems Biology Division
Axel Visel: Environmental Genomics and Systems Biology Division
Len A. Pennacchio: Environmental Genomics and Systems Biology Division

Nature, 2018, vol. 554, issue 7691, 239-243

Abstract: Gene enhancer knockout phenotypes and analysis of enhancer activity patterns show that developmental genes are regulated by multiple redundant enhancers in mouse embryos.

Date: 2018
References: Add references at CitEc
Citations: View citations in EconPapers (16)

Downloads: (external link)
https://www.nature.com/articles/nature25461 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:554:y:2018:i:7691:d:10.1038_nature25461

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature25461

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().