Dynamic basis for dG•dT misincorporation via tautomerization and ionization

Isaac J. Kimsey, Eric S. Szymanski, Walter J. Zahurancik, Anisha Shakya, Yi Xue, Chia-Chieh Chu, Bharathwaj Sathyamoorthy, Zucai Suo () and Hashim M. Al-Hashimi ()
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Isaac J. Kimsey: Duke University Medical Center
Eric S. Szymanski: Duke University Medical Center
Walter J. Zahurancik: The Ohio State University
Anisha Shakya: University of Michigan
Yi Xue: Duke University Medical Center
Chia-Chieh Chu: Duke University Medical Center
Bharathwaj Sathyamoorthy: Duke University Medical Center
Zucai Suo: The Ohio State University
Hashim M. Al-Hashimi: Duke University Medical Center

Nature, 2018, vol. 554, issue 7691, 195-201

Abstract: A kinetic model is proposed to predict the probability of dG•dT misincorporation across different polymerases, and provides mechanisms for sequence-dependent misincorporation.

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:554:y:2018:i:7691:d:10.1038_nature25487

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DOI: 10.1038/nature25487

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