Asparagine bioavailability governs metastasis in a model of breast cancer

Simon R. V. Knott, Elvin Wagenblast, Showkhin Khan, Sun Y. Kim, Mar Soto, Michel Wagner, Marc-Olivier Turgeon, Lisa Fish, Nicolas Erard, Annika L. Gable, Ashley R. Maceli, Steffen Dickopf, Evangelia K. Papachristou, Clive S. D’Santos, Lisa A. Carey, John E. Wilkinson, J. Chuck Harrell, Charles M. Perou, Hani Goodarzi, George Poulogiannis and Gregory J. Hannon ()
Additional contact information
Simon R. V. Knott: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way
Elvin Wagenblast: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor
Showkhin Khan: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor
Sun Y. Kim: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor
Mar Soto: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor
Michel Wagner: The Institute of Cancer Research
Marc-Olivier Turgeon: The Institute of Cancer Research
Lisa Fish: University of California, San Francisco
Nicolas Erard: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way
Annika L. Gable: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor
Ashley R. Maceli: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor
Steffen Dickopf: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor
Evangelia K. Papachristou: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way
Clive S. D’Santos: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way
Lisa A. Carey: University of North Carolina at Chapel Hill, 170 Manning Drive, CB7305
John E. Wilkinson: University of Michigan School of Medicine
J. Chuck Harrell: Virginia Commonwealth University
Charles M. Perou: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Hani Goodarzi: University of California, San Francisco
George Poulogiannis: The Institute of Cancer Research
Gregory J. Hannon: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way

Nature, 2018, vol. 554, issue 7692, 378-381

Abstract: In a mouse model of breast cancer, asparagine bioavailability strongly influences metastasis and this is correlated with the production of proteins that regulate the epithelial-to-mesenchymal transition, which provides at least one potential mechanism for how a single amino acid could regulate metastatic progression.

Date: 2018
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DOI: 10.1038/nature25465

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