Structural basis for DNMT3A-mediated de novo DNA methylation

Zhi-Min Zhang, Rui Lu, Pengcheng Wang, Yang Yu, Dongliang Chen, Linfeng Gao, Shuo Liu, Debin Ji, Scott B Rothbart, Yinsheng Wang, Gang Greg Wang () and Jikui Song ()
Additional contact information
Zhi-Min Zhang: University of California
Rui Lu: The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
Pengcheng Wang: Environmental Toxicology Graduate Program, University of California
Yang Yu: Environmental Toxicology Graduate Program, University of California
Dongliang Chen: The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
Linfeng Gao: Environmental Toxicology Graduate Program, University of California
Shuo Liu: Environmental Toxicology Graduate Program, University of California
Debin Ji: University of California
Scott B Rothbart: University of North Carolina at Chapel Hill School of Medicine
Yinsheng Wang: Environmental Toxicology Graduate Program, University of California
Gang Greg Wang: The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
Jikui Song: University of California

Nature, 2018, vol. 554, issue 7692, 387-391

Abstract: A crystal structure of DNMT3A and its regulatory partner DNMT3L bound to DNA reveals the mechanistic basis for DNMT3A-mediated DNA methylation and establishes its aetiological link to human disease.

Date: 2018
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DOI: 10.1038/nature25477

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