TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

Daniele V. F. Tauriello, Sergio Palomo-Ponce, Diana Stork, Antonio Berenguer-Llergo, Jordi Badia-Ramentol, Mar Iglesias, Marta Sevillano, Sales Ibiza, Adrià Cañellas, Xavier Hernando-Momblona, Daniel Byrom, Joan A. Matarin, Alexandre Calon, Elisa I. Rivas, Angel R. Nebreda, Antoni Riera, Camille Stephan-Otto Attolini and Eduard Batlle ()
Additional contact information
Daniele V. F. Tauriello: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Sergio Palomo-Ponce: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Diana Stork: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Antonio Berenguer-Llergo: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Jordi Badia-Ramentol: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Mar Iglesias: Centro de Investigación Biomédica en Red de Cáncer (CIBERONC)
Marta Sevillano: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Sales Ibiza: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Adrià Cañellas: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Xavier Hernando-Momblona: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Daniel Byrom: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Joan A. Matarin: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Alexandre Calon: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Elisa I. Rivas: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Angel R. Nebreda: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Antoni Riera: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Camille Stephan-Otto Attolini: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Eduard Batlle: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology

Nature, 2018, vol. 554, issue 7693, 538-543

Abstract: A combination of TGFβ inhibition and checkpoint-inhibition therapy provokes a potent cytotoxic response against metastatic tumours derived from colorectal cancers in mice.

Date: 2018
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DOI: 10.1038/nature25492

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