TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Sanjeev Mariathasan (), Shannon J. Turley (), Dorothee Nickles, Alessandra Castiglioni, Kobe Yuen, Yulei Wang, Edward E. Kadel, Hartmut Koeppen, Jillian L. Astarita, Rafael Cubas, Suchit Jhunjhunwala, Romain Banchereau, Yagai Yang, Yinghui Guan, Cecile Chalouni, James Ziai, Yasin Şenbabaoğlu, Stephen Santoro, Daniel Sheinson, Jeffrey Hung, Jennifer M. Giltnane, Andrew A. Pierce, Kathryn Mesh, Steve Lianoglou, Johannes Riegler, Richard A. D. Carano, Pontus Eriksson, Mattias Höglund, Loan Somarriba, Daniel L. Halligan, Michiel S. van der Heijden, Yohann Loriot, Jonathan E. Rosenberg, Lawrence Fong, Ira Mellman, Daniel S. Chen, Marjorie Green, Christina Derleth, Gregg D. Fine, Priti S. Hegde, Richard Bourgon () and Thomas Powles
Additional contact information
Sanjeev Mariathasan: Genentech, South San Francisco
Shannon J. Turley: Genentech, South San Francisco
Dorothee Nickles: Genentech, South San Francisco
Alessandra Castiglioni: Genentech, South San Francisco
Kobe Yuen: Genentech, South San Francisco
Yulei Wang: Genentech, South San Francisco
Edward E. Kadel: Genentech, South San Francisco
Hartmut Koeppen: Genentech, South San Francisco
Jillian L. Astarita: Genentech, South San Francisco
Rafael Cubas: Genentech, South San Francisco
Suchit Jhunjhunwala: Genentech, South San Francisco
Romain Banchereau: Genentech, South San Francisco
Yagai Yang: Genentech, South San Francisco
Yinghui Guan: Genentech, South San Francisco
Cecile Chalouni: Genentech, South San Francisco
James Ziai: Genentech, South San Francisco
Yasin Şenbabaoğlu: Genentech, South San Francisco
Stephen Santoro: Genentech, South San Francisco
Daniel Sheinson: Genentech, South San Francisco
Jeffrey Hung: Genentech, South San Francisco
Jennifer M. Giltnane: Genentech, South San Francisco
Andrew A. Pierce: Genentech, South San Francisco
Kathryn Mesh: Genentech, South San Francisco
Steve Lianoglou: Genentech, South San Francisco
Johannes Riegler: Genentech, South San Francisco
Richard A. D. Carano: Genentech, South San Francisco
Pontus Eriksson: Lund University
Mattias Höglund: Lund University
Loan Somarriba: Fios Genomics
Daniel L. Halligan: Fios Genomics
Michiel S. van der Heijden: Netherlands Cancer Institute
Yohann Loriot: Institut Gustave Roussy, University of Paris Sud
Jonathan E. Rosenberg: Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center
Lawrence Fong: University of California San Francisco, Helen Diller Family Comprehensive Cancer Center
Ira Mellman: Genentech, South San Francisco
Daniel S. Chen: Genentech, South San Francisco
Marjorie Green: Genentech, South San Francisco
Christina Derleth: Genentech, South San Francisco
Gregg D. Fine: Genentech, South San Francisco
Priti S. Hegde: Genentech, South San Francisco
Richard Bourgon: Genentech, South San Francisco
Thomas Powles: Barts Experimental Cancer Medicine Centre, Barts Cancer Institute, Queen Mary University of London

Nature, 2018, vol. 554, issue 7693, 544-548

Abstract: In humans, TGFβ signalling is associated with lack of response to immunotherapy in immune-excluded tumours; in mouse models of this immune phenotype, robust tumour infiltration by T cells and tumour regression are observed only when checkpoint inhibition is combined with inhibition of TGFβ signalling.

Date: 2018
References: Add references at CitEc
Citations: View citations in EconPapers (43)

Downloads: (external link)
https://www.nature.com/articles/nature25501 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:554:y:2018:i:7693:d:10.1038_nature25501

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature25501

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().