Palladium-catalysed electrophilic aromatic C–H fluorination

Kumiko Yamamoto, Jiakun Li, Jeffrey A. O. Garber, Julian D. Rolfes, Gregory B. Boursalian, Jannik C. Borghs, Christophe Genicot, Jérôme Jacq, Maurice van Gastel, Frank Neese and Tobias Ritter ()
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Kumiko Yamamoto: Max-Planck-Institut für Kohlenforschung
Jiakun Li: Max-Planck-Institut für Kohlenforschung
Jeffrey A. O. Garber: Max-Planck-Institut für Kohlenforschung
Julian D. Rolfes: Max-Planck-Institut für Kohlenforschung
Gregory B. Boursalian: Max-Planck-Institut für Kohlenforschung
Jannik C. Borghs: Harvard University
Christophe Genicot: Global Chemistry, UCB NewMedicines, UCB Biopharma
Jérôme Jacq: Global Chemistry, UCB NewMedicines, UCB Biopharma
Maurice van Gastel: Max-Planck-Institut für Kohlenforschung
Frank Neese: Max-Planck-Institut für Kohlenforschung
Tobias Ritter: Max-Planck-Institut für Kohlenforschung

Nature, 2018, vol. 554, issue 7693, 511-514

Abstract: An approach for the direct electrophilic C–H fluorination of arenes is reported, using a palladium catalyst and mild fluorinating reagents.

Date: 2018
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DOI: 10.1038/nature25749

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