Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas

Isidoro Cobo, Paola Martinelli, Marta Flández, Latifa Bakiri, Mingfeng Zhang, Enrique Carrillo- de-Santa-Pau, Jinping Jia, Víctor J. Sánchez-Arévalo Lobo, Diego Megías, Irene Felipe, Natalia del Pozo, Irene Millán, Liv Thommesen, Torunn Bruland, Sara H. Olson, Jill Smith, Kristina Schoonjans, William R. Bamlet, Gloria M. Petersen, Núria Malats, Laufey T. Amundadottir, Erwin F. Wagner and Francisco X. Real ()
Additional contact information
Isidoro Cobo: Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO
Paola Martinelli: Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO
Marta Flández: Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO
Latifa Bakiri: Genes, Development, and Disease Group, Spanish National Cancer Research Centre-CNIO
Mingfeng Zhang: Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
Enrique Carrillo- de-Santa-Pau: Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO
Jinping Jia: Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
Víctor J. Sánchez-Arévalo Lobo: Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO
Diego Megías: Confocal Microscopy Unit, Spanish National Cancer Research Centre-CNIO
Irene Felipe: Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO
Natalia del Pozo: Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO
Irene Millán: Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO
Liv Thommesen: Norwegian University of Science and Technology (NTNU)
Torunn Bruland: Clinic of Medicine, St. Olav’s University Hospital
Sara H. Olson: Memorial Sloan Kettering Cancer Center, New York
Jill Smith: Georgetown University
Kristina Schoonjans: Ecole Polytechnique Fédérale de Lausanne
William R. Bamlet: Mayo Clinic
Gloria M. Petersen: Mayo Clinic
Núria Malats: Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre-CNIO
Laufey T. Amundadottir: Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
Erwin F. Wagner: Genes, Development, and Disease Group, Spanish National Cancer Research Centre-CNIO
Francisco X. Real: Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO

Nature, 2018, vol. 554, issue 7693, 533-537

Abstract: In mouse pancreas cells with only one copy of the Nr5a2 gene, the orphan nuclear receptor NR5A2 undergoes a marked transcriptional shift from differentiation-specific to inflammatory genes, which results in an epithelial-cell-autonomous basal pre-inflammatory state.

Date: 2018
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DOI: 10.1038/nature25751

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