Whole-organism clone tracing using single-cell sequencing

Anna Alemany, Maria Florescu, Chloé S. Baron, Josi Peterson-Maduro and Alexander van Oudenaarden ()
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Anna Alemany: Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht
Maria Florescu: Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht
Chloé S. Baron: Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht
Josi Peterson-Maduro: Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht
Alexander van Oudenaarden: Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht

Nature, 2018, vol. 556, issue 7699, 108-112

Abstract: A single-cell sequencing method is developed that uses transcriptomics and CRISPR–Cas9 technology to investigate clonal relationships in cells present in different zebrafish tissues.

Date: 2018
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DOI: 10.1038/nature25969

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