Molecular nucleation mechanisms and control strategies for crystal polymorph selection

Alexander E. S. Van Driessche (), Nani Van Gerven, Paul H. H. Bomans, Rick R. M. Joosten, Heiner Friedrich, David Gil-Carton, Nico A. J. M. Sommerdijk and Mike Sleutel ()
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Alexander E. S. Van Driessche: Université Grenoble Alpes, Université Savoie Mont Blanc, CNRS, IRD, IFSTTAR, ISTerre
Nani Van Gerven: Structural Biology Brussels, Vrije Universiteit Brussel
Paul H. H. Bomans: Laboratory of Materials and Interface Chemistry and Center of Multiscale Electron Microscopy, Eindhoven University of Technology
Rick R. M. Joosten: Laboratory of Materials and Interface Chemistry and Center of Multiscale Electron Microscopy, Eindhoven University of Technology
Heiner Friedrich: Laboratory of Materials and Interface Chemistry and Center of Multiscale Electron Microscopy, Eindhoven University of Technology
David Gil-Carton: Structural Biology Unit, CIC bioGUNE, Parque Tecnológico de Bizkaia
Nico A. J. M. Sommerdijk: Laboratory of Materials and Interface Chemistry and Center of Multiscale Electron Microscopy, Eindhoven University of Technology
Mike Sleutel: Structural Biology Brussels, Vrije Universiteit Brussel

Nature, 2018, vol. 556, issue 7699, 89-94

Abstract: Cryo-transmission electron microscopy reveals the initiation of glucose isomerase crystals and their growth into different crystalline or gel polymorphs, and shows that mutating specific amino acids controls which polymorph grows.

Date: 2018
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DOI: 10.1038/nature25971

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