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Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel

Ji She, Jiangtao Guo, Qingfeng Chen, Weizhong Zeng, Youxing Jiang () and Xiao-chen Bai ()
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Ji She: University of Texas Southwestern Medical Center
Jiangtao Guo: Zhejiang University School of Medicine
Qingfeng Chen: University of Texas Southwestern Medical Center
Weizhong Zeng: University of Texas Southwestern Medical Center
Youxing Jiang: University of Texas Southwestern Medical Center
Xiao-chen Bai: University of Texas Southwestern Medical Center

Nature, 2018, vol. 556, issue 7699, 130-134

Abstract: Structures of the voltage-gated and phosphatidylinositol 3,5-bisphosphate-activated mouse two-pore channel TPC1 in apo and ligand-bound states provide insights into the selectivity and gating mechanisms of mammalian two-pore channels.

Date: 2018
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DOI: 10.1038/nature26139

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