Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis

Giovanna Scapin (), Venkata P. Dandey, Zhening Zhang, Winifred Prosise, Alan Hruza, Theresa Kelly, Todd Mayhood, Corey Strickland, Clinton S. Potter and Bridget Carragher
Additional contact information
Giovanna Scapin: Merck & Co.
Venkata P. Dandey: Simons Electron Microscopy Center, National Resource for Automated Molecular Microscopy, New York Structural Biology Center
Zhening Zhang: Simons Electron Microscopy Center, National Resource for Automated Molecular Microscopy, New York Structural Biology Center
Winifred Prosise: Merck & Co.
Alan Hruza: Merck & Co.
Theresa Kelly: Merck & Co., NMR & Protein Products Characterization
Todd Mayhood: Merck & Co., NMR & Protein Products Characterization
Corey Strickland: Merck & Co.
Clinton S. Potter: Simons Electron Microscopy Center, National Resource for Automated Molecular Microscopy, New York Structural Biology Center
Bridget Carragher: Simons Electron Microscopy Center, National Resource for Automated Molecular Microscopy, New York Structural Biology Center

Nature, 2018, vol. 556, issue 7699, 122-125

Abstract: Cryo-electron microscopy structures of insulin in a complex with the insulin receptor define the S2 binding site on the receptor and suggest a mechanism for downstream propagation of insulin signalling.

Date: 2018
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DOI: 10.1038/nature26153

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