A new class of synthetic retinoid antibiotics effective against bacterial persisters

Wooseong Kim, Wenpeng Zhu, Gabriel Lambert Hendricks, Daria Van Tyne, Andrew D. Steele, Colleen E. Keohane, Nico Fricke, Annie L. Conery, Steven Shen, Wen Pan, Kiho Lee, Rajmohan Rajamuthiah, Beth Burgwyn Fuchs, Petia M. Vlahovska, William M. Wuest, Michael S. Gilmore, Huajian Gao, Frederick M. Ausubel and Eleftherios Mylonakis ()
Additional contact information
Wooseong Kim: Rhode Island Hospital, Warren Alpert Medical School of Brown University
Wenpeng Zhu: School of Engineering, Brown University
Gabriel Lambert Hendricks: Rhode Island Hospital, Warren Alpert Medical School of Brown University
Daria Van Tyne: Harvard Medical School, Massachusetts Eye and Ear Infirmary
Andrew D. Steele: Emory University
Colleen E. Keohane: Emory University
Nico Fricke: School of Engineering, Brown University
Annie L. Conery: Massachusetts General Hospital
Steven Shen: Rhode Island Hospital, Warren Alpert Medical School of Brown University
Wen Pan: Rhode Island Hospital, Warren Alpert Medical School of Brown University
Kiho Lee: Rhode Island Hospital, Warren Alpert Medical School of Brown University
Rajmohan Rajamuthiah: Rhode Island Hospital, Warren Alpert Medical School of Brown University
Beth Burgwyn Fuchs: Rhode Island Hospital, Warren Alpert Medical School of Brown University
Petia M. Vlahovska: Northwestern University
William M. Wuest: Emory University
Michael S. Gilmore: Harvard Medical School, Massachusetts Eye and Ear Infirmary
Huajian Gao: School of Engineering, Brown University
Frederick M. Ausubel: Massachusetts General Hospital
Eleftherios Mylonakis: Rhode Island Hospital, Warren Alpert Medical School of Brown University

Nature, 2018, vol. 556, issue 7699, 103-107

Abstract: Synthetic retinoid compounds can kill both growing and persister MRSA cells by disrupting the membrane lipid bilayer, and are effective in a mouse model of chronic MRSA infection.

Date: 2018
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DOI: 10.1038/nature26157

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