Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin

Peng Zhou, Hang Fan, Tian Lan, Xing-Lou Yang, Wei-Feng Shi, Wei Zhang, Yan Zhu, Ya-Wei Zhang, Qing-Mei Xie, Shailendra Mani, Xiao-Shuang Zheng, Bei Li, Jin-Man Li, Hua Guo, Guang-Qian Pei, Xiao-Ping An, Jun-Wei Chen, Ling Zhou, Kai-Jie Mai, Zi-Xian Wu, Di Li, Danielle E. Anderson, Li-Biao Zhang, Shi-Yue Li, Zhi-Qiang Mi, Tong-Tong He, Feng Cong, Peng-Ju Guo, Ren Huang, Yun Luo, Xiang-Ling Liu, Jing Chen, Yong Huang, Qiang Sun, Xiang-Li-Lan Zhang, Yuan-Yuan Wang, Shao-Zhen Xing, Yan-Shan Chen, Yuan Sun, Juan Li, Peter Daszak (), Lin-Fa Wang (), Zheng-Li Shi (), Yi-Gang Tong () and Jing-Yun Ma ()
Additional contact information
Peng Zhou: Chinese Academy of Sciences
Hang Fan: Beijing Institute of Microbiology and Epidemiology
Tian Lan: South China Agricultural University
Xing-Lou Yang: Chinese Academy of Sciences
Wei-Feng Shi: Taishan Medical College
Wei Zhang: Chinese Academy of Sciences
Yan Zhu: Chinese Academy of Sciences
Ya-Wei Zhang: Beijing Institute of Microbiology and Epidemiology
Qing-Mei Xie: South China Agricultural University
Shailendra Mani: Duke-NUS Medical School
Xiao-Shuang Zheng: Chinese Academy of Sciences
Bei Li: Chinese Academy of Sciences
Jin-Man Li: Beijing Institute of Microbiology and Epidemiology
Hua Guo: Chinese Academy of Sciences
Guang-Qian Pei: Beijing Institute of Microbiology and Epidemiology
Xiao-Ping An: Beijing Institute of Microbiology and Epidemiology
Jun-Wei Chen: South China Agricultural University
Ling Zhou: South China Agricultural University
Kai-Jie Mai: South China Agricultural University
Zi-Xian Wu: South China Agricultural University
Di Li: South China Agricultural University
Danielle E. Anderson: Duke-NUS Medical School
Li-Biao Zhang: Guangdong Institute of Applied Biological Resources
Shi-Yue Li: Wuhan University
Zhi-Qiang Mi: Beijing Institute of Microbiology and Epidemiology
Tong-Tong He: Beijing Institute of Microbiology and Epidemiology
Feng Cong: Guangdong Laboratory Animals Monitoring Institute
Peng-Ju Guo: Guangdong Laboratory Animals Monitoring Institute
Ren Huang: Guangdong Laboratory Animals Monitoring Institute
Yun Luo: Chinese Academy of Sciences
Xiang-Ling Liu: Chinese Academy of Sciences
Jing Chen: Chinese Academy of Sciences
Yong Huang: Beijing Institute of Microbiology and Epidemiology
Qiang Sun: Beijing Institute of Microbiology and Epidemiology
Xiang-Li-Lan Zhang: Beijing Institute of Microbiology and Epidemiology
Yuan-Yuan Wang: Beijing Institute of Microbiology and Epidemiology
Shao-Zhen Xing: Beijing Institute of Microbiology and Epidemiology
Yan-Shan Chen: South China Agricultural University
Yuan Sun: South China Agricultural University
Juan Li: Taishan Medical College
Peter Daszak: EcoHealth Alliance
Lin-Fa Wang: Duke-NUS Medical School
Zheng-Li Shi: Chinese Academy of Sciences
Yi-Gang Tong: Beijing Institute of Microbiology and Epidemiology
Jing-Yun Ma: South China Agricultural University

Nature, 2018, vol. 556, issue 7700, 255-258

Abstract: Abstract Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health 1 . Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS) 2–10 . Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms. Notably, the outbreak began in Guangdong province in the vicinity of the origin of the SARS pandemic. Furthermore, we identified SADS-related CoVs with 96–98% sequence identity in 9.8% (58 out of 591) of anal swabs collected from bats in Guangdong province during 2013–2016, predominantly in horseshoe bats (Rhinolophus spp.) that are known reservoirs of SARS-related CoVs. We found that there were striking similarities between the SADS and SARS outbreaks in geographical, temporal, ecological and aetiological settings. This study highlights the importance of identifying coronavirus diversity and distribution in bats to mitigate future outbreaks that could threaten livestock, public health and economic growth.

Date: 2018
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DOI: 10.1038/s41586-018-0010-9

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