Identification of the tumour transition states occurring during EMT

Ievgenia Pastushenko, Audrey Brisebarre, Alejandro Sifrim, Marco Fioramonti, Tatiana Revenco, Soufiane Boumahdi, Alexandra Van Keymeulen, Daniel Brown, Virginie Moers, Sophie Lemaire, Sarah De Clercq, Esmeralda Minguijón, Cédric Balsat, Youri Sokolow, Christine Dubois, Florian De Cock, Samuel Scozzaro, Federico Sopena, Angel Lanas, Nicky D’Haene, Isabelle Salmon, Jean-Christophe Marine, Thierry Voet, Panagiota A. Sotiropoulou and Cédric Blanpain ()
Additional contact information
Ievgenia Pastushenko: Université Libre de Buxelles
Audrey Brisebarre: Université Libre de Buxelles
Alejandro Sifrim: University of Leuven
Marco Fioramonti: Université Libre de Buxelles
Tatiana Revenco: Université Libre de Buxelles
Soufiane Boumahdi: Université Libre de Buxelles
Alexandra Van Keymeulen: Université Libre de Buxelles
Daniel Brown: University of Leuven
Virginie Moers: Université Libre de Buxelles
Sophie Lemaire: Université Libre de Buxelles
Sarah De Clercq: Université Libre de Bruxelles
Esmeralda Minguijón: Université Libre de Bruxelles
Cédric Balsat: Université Libre de Bruxelles
Youri Sokolow: Université Libre de Bruxelles
Christine Dubois: Université Libre de Buxelles
Florian De Cock: Université Libre de Buxelles
Samuel Scozzaro: Université Libre de Buxelles
Federico Sopena: Hospital Clínico Universitario “Lozano Blesa”, IIS Aragon
Angel Lanas: University of Zaragoza
Nicky D’Haene: Université Libre de Bruxelles
Isabelle Salmon: Université Libre de Bruxelles
Jean-Christophe Marine: VIB Center for Cancer Biology
Thierry Voet: University of Leuven
Panagiota A. Sotiropoulou: Université Libre de Buxelles
Cédric Blanpain: Université Libre de Buxelles

Nature, 2018, vol. 556, issue 7702, 463-468

Abstract: Abstract In cancer, the epithelial-to-mesenchymal transition (EMT) is associated with tumour stemness, metastasis and resistance to therapy. It has recently been proposed that, rather than being a binary process, EMT occurs through distinct intermediate states. However, there is no direct in vivo evidence for this idea. Here we screen a large panel of cell surface markers in skin and mammary primary tumours, and identify the existence of multiple tumour subpopulations associated with different EMT stages: from epithelial to completely mesenchymal states, passing through intermediate hybrid states. Although all EMT subpopulations presented similar tumour-propagating cell capacity, they displayed differences in cellular plasticity, invasiveness and metastatic potential. Their transcriptional and epigenetic landscapes identify the underlying gene regulatory networks, transcription factors and signalling pathways that control these different EMT transition states. Finally, these tumour subpopulations are localized in different niches that differentially regulate EMT transition states.

Date: 2018
References: Add references at CitEc
Citations: View citations in EconPapers (10)

Downloads: (external link)
https://www.nature.com/articles/s41586-018-0040-3 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:556:y:2018:i:7702:d:10.1038_s41586-018-0040-3

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/s41586-018-0040-3

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().