Pancreas regeneration

Qiao Zhou () and Douglas A. Melton ()
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Qiao Zhou: Harvard University
Douglas A. Melton: Harvard University

Nature, 2018, vol. 557, issue 7705, 351-358

Abstract: Abstract The pancreas is made from two distinct components: the exocrine pancreas, a reservoir of digestive enzymes, and the endocrine islets, the source of the vital metabolic hormone insulin. Human islets possess limited regenerative ability; loss of islet β-cells in diseases such as type 1 diabetes requires therapeutic intervention. The leading strategy for restoration of β-cell mass is through the generation and transplantation of new β-cells derived from human pluripotent stem cells. Other approaches include stimulating endogenous β-cell proliferation, reprogramming non-β-cells to β-like cells, and harvesting islets from genetically engineered animals. Together these approaches form a rich pipeline of therapeutic development for pancreatic regeneration.

Date: 2018
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DOI: 10.1038/s41586-018-0088-0

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