A circuit from hippocampal CA2 to lateral septum disinhibits social aggression

Felix Leroy (), Jung Park, Arun Asok, David H. Brann, Torcato Meira, Lara M. Boyle, Eric W. Buss, Eric R. Kandel and Steven A. Siegelbaum ()
Additional contact information
Felix Leroy: Columbia University
Jung Park: Columbia University
Arun Asok: Columbia University
David H. Brann: Columbia University
Torcato Meira: Columbia University
Lara M. Boyle: Columbia University
Eric W. Buss: Columbia University
Eric R. Kandel: Columbia University
Steven A. Siegelbaum: Columbia University

Nature, 2018, vol. 564, issue 7735, 213-218

Abstract: Abstract Although the hippocampus is known to be important for declarative memory, it is less clear how hippocampal output regulates motivated behaviours, such as social aggression. Here we report that pyramidal neurons in the CA2 region of the hippocampus, which are important for social memory, promote social aggression in mice. This action depends on output from CA2 to the lateral septum, which is selectively enhanced immediately before an attack. Activation of the lateral septum by CA2 recruits a circuit that disinhibits a subnucleus of the ventromedial hypothalamus that is known to trigger attack. The social hormone arginine vasopressin enhances social aggression by acting on arginine vasopressin 1b receptors on CA2 presynaptic terminals in the lateral septum to facilitate excitatory synaptic transmission. In this manner, release of arginine vasopressin in the lateral septum, driven by an animal’s internal state, may serve as a modulatory control that determines whether CA2 activity leads to declarative memory of a social encounter and/or promotes motivated social aggression.

Keywords: Social Aggression; Lateral Septum (LS); Resident Intruder Test; Fiber Photometry; Secondary Incubation (search for similar items in EconPapers)
Date: 2018
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DOI: 10.1038/s41586-018-0772-0

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