Thermal stress induces glycolytic beige fat formation via a myogenic state

Yong Chen, Kenji Ikeda, Takeshi Yoneshiro, Annarita Scaramozza, Kazuki Tajima, Qiang Wang, Kyeongkyu Kim, Kosaku Shinoda, Carlos Henrique Sponton, Zachary Brown, Andrew Brack and Shingo Kajimura ()
Additional contact information
Yong Chen: UCSF Diabetes Center
Kenji Ikeda: UCSF Diabetes Center
Takeshi Yoneshiro: UCSF Diabetes Center
Annarita Scaramozza: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
Kazuki Tajima: UCSF Diabetes Center
Qiang Wang: UCSF Diabetes Center
Kyeongkyu Kim: UCSF Diabetes Center
Kosaku Shinoda: UCSF Diabetes Center
Carlos Henrique Sponton: UCSF Diabetes Center
Zachary Brown: UCSF Diabetes Center
Andrew Brack: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
Shingo Kajimura: UCSF Diabetes Center

Nature, 2019, vol. 565, issue 7738, 180-185

Abstract: Abstract Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue. However, the molecular mechanisms by which physiological or pathological cues evoke developmental plasticity remain incompletely understood. Here we report a type of beige adipocyte that has a critical role in chronic cold adaptation in the absence of β-adrenergic receptor signalling. This beige fat is distinct from conventional beige fat with respect to developmental origin and regulation, and displays enhanced glucose oxidation. We therefore refer to it as glycolytic beige fat. Mechanistically, we identify GA-binding protein α as a regulator of glycolytic beige adipocyte differentiation through a myogenic intermediate. Our study reveals a non-canonical adaptive mechanism by which thermal stress induces progenitor cell plasticity and recruits a distinct form of thermogenic cell that is required for energy homeostasis and survival.

Date: 2019
References: Add references at CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.nature.com/articles/s41586-018-0801-z Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:565:y:2019:i:7738:d:10.1038_s41586-018-0801-z

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/s41586-018-0801-z

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().