Sleep modulates haematopoiesis and protects against atherosclerosis

Cameron S. McAlpine, Máté G. Kiss, Sara Rattik, Shun He, Anne Vassalli, Colin Valet, Atsushi Anzai, Christopher T. Chan, John E. Mindur, Florian Kahles, Wolfram C. Poller, Vanessa Frodermann, Ashley M. Fenn, Annemijn F. Gregory, Lennard Halle, Yoshiko Iwamoto, Friedrich F. Hoyer, Christoph J. Binder, Peter Libby, Mehdi Tafti, Thomas E. Scammell, Matthias Nahrendorf and Filip K. Swirski ()
Additional contact information
Cameron S. McAlpine: Massachusetts General Hospital and Harvard Medical School
Máté G. Kiss: Massachusetts General Hospital and Harvard Medical School
Sara Rattik: Massachusetts General Hospital and Harvard Medical School
Shun He: Massachusetts General Hospital and Harvard Medical School
Anne Vassalli: University of Lausanne
Colin Valet: Massachusetts General Hospital and Harvard Medical School
Atsushi Anzai: Massachusetts General Hospital and Harvard Medical School
Christopher T. Chan: Massachusetts General Hospital and Harvard Medical School
John E. Mindur: Massachusetts General Hospital and Harvard Medical School
Florian Kahles: Massachusetts General Hospital and Harvard Medical School
Wolfram C. Poller: Massachusetts General Hospital and Harvard Medical School
Vanessa Frodermann: Massachusetts General Hospital and Harvard Medical School
Ashley M. Fenn: Massachusetts General Hospital and Harvard Medical School
Annemijn F. Gregory: Massachusetts General Hospital and Harvard Medical School
Lennard Halle: Massachusetts General Hospital and Harvard Medical School
Yoshiko Iwamoto: Massachusetts General Hospital and Harvard Medical School
Friedrich F. Hoyer: Massachusetts General Hospital and Harvard Medical School
Christoph J. Binder: Medical University of Vienna
Peter Libby: Brigham and Women’s Hospital
Mehdi Tafti: University of Lausanne
Thomas E. Scammell: Beth Israel Deaconess Medical Center
Matthias Nahrendorf: Massachusetts General Hospital and Harvard Medical School
Filip K. Swirski: Massachusetts General Hospital and Harvard Medical School

Nature, 2019, vol. 566, issue 7744, 383-387

Abstract: Abstract Sleep is integral to life1. Although insufficient or disrupted sleep increases the risk of multiple pathological conditions, including cardiovascular disease2, we know little about the cellular and molecular mechanisms by which sleep maintains cardiovascular health. Here we report that sleep regulates haematopoiesis and protects against atherosclerosis in mice. We show that mice subjected to sleep fragmentation produce more Ly-6Chigh monocytes, develop larger atherosclerotic lesions and produce less hypocretin—a stimulatory and wake-promoting neuropeptide—in the lateral hypothalamus. Hypocretin controls myelopoiesis by restricting the production of CSF1 by hypocretin-receptor-expressing pre-neutrophils in the bone marrow. Whereas hypocretin-null and haematopoietic hypocretin-receptor-null mice develop monocytosis and accelerated atherosclerosis, sleep-fragmented mice with either haematopoietic CSF1 deficiency or hypocretin supplementation have reduced numbers of circulating monocytes and smaller atherosclerotic lesions. Together, these results identify a neuro-immune axis that links sleep to haematopoiesis and atherosclerosis.

Date: 2019
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/s41586-019-0948-2 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:566:y:2019:i:7744:d:10.1038_s41586-019-0948-2

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/s41586-019-0948-2

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().