Gene expression across mammalian organ development

Margarida Cardoso-Moreira (), Jean Halbert, Delphine Valloton, Britta Velten, Chunyan Chen, Yi Shao, Angélica Liechti, Kelly Ascenção, Coralie Rummel, Svetlana Ovchinnikova, Pavel V. Mazin, Ioannis Xenarios, Keith Harshman, Matthew Mort, David N. Cooper, Carmen Sandi, Michael J. Soares, Paula G. Ferreira, Sandra Afonso, Miguel Carneiro, James M. A. Turner, John L. VandeBerg, Amir Fallahshahroudi, Per Jensen, Rüdiger Behr, Steven Lisgo, Susan Lindsay, Philipp Khaitovich, Wolfgang Huber, Julie Baker, Simon Anders, Yong E. Zhang and Henrik Kaessmann ()
Additional contact information
Margarida Cardoso-Moreira: Center for Molecular Biology of Heidelberg University (ZMBH)
Jean Halbert: University of Lausanne
Delphine Valloton: University of Lausanne
Britta Velten: European Molecular Biology Laboratory
Chunyan Chen: Chinese Academy of Sciences
Yi Shao: Chinese Academy of Sciences
Angélica Liechti: University of Lausanne
Kelly Ascenção: University of Lausanne
Coralie Rummel: University of Lausanne
Svetlana Ovchinnikova: Center for Molecular Biology of Heidelberg University (ZMBH)
Pavel V. Mazin: Skolkovo Institute of Science and Technology
Ioannis Xenarios: University of Lausanne
Keith Harshman: University of Lausanne
Matthew Mort: Cardiff University
David N. Cooper: Cardiff University
Carmen Sandi: Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL)
Michael J. Soares: University of Kansas Medical Center
Paula G. Ferreira: Universidade do Porto
Sandra Afonso: Universidade do Porto
Miguel Carneiro: Universidade do Porto
James M. A. Turner: The Francis Crick Institute
John L. VandeBerg: The University of Texas Rio Grande Valley, Brownsville
Amir Fallahshahroudi: Linköping University
Per Jensen: Linköping University
Rüdiger Behr: Leibniz Institute for Primate Research (DPZ)
Steven Lisgo: Newcastle University
Susan Lindsay: Newcastle University
Philipp Khaitovich: Skolkovo Institute of Science and Technology
Wolfgang Huber: European Molecular Biology Laboratory
Julie Baker: Stanford University School of Medicine
Simon Anders: Center for Molecular Biology of Heidelberg University (ZMBH)
Yong E. Zhang: Chinese Academy of Sciences
Henrik Kaessmann: Center for Molecular Biology of Heidelberg University (ZMBH)

Nature, 2019, vol. 571, issue 7766, 505-509

Abstract: Abstract The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early organogenesis to adulthood for human, rhesus macaque, mouse, rat, rabbit, opossum and chicken. Comparisons of gene expression patterns identified correspondences of developmental stages across species, and differences in the timing of key events during the development of the gonads. We found that the breadth of gene expression and the extent of purifying selection gradually decrease during development, whereas the amount of positive selection and expression of new genes increase. We identified differences in the temporal trajectories of expression of individual genes across species, with brain tissues showing the smallest percentage of trajectory changes, and the liver and testis showing the largest. Our work provides a resource of developmental transcriptomes of seven organs across seven species, and comparative analyses that characterize the development and evolution of mammalian organs.

Date: 2019
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DOI: 10.1038/s41586-019-1338-5

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