Conserved cell types with divergent features in human versus mouse cortex

Hodge, Rebecca D.; Bakken, Trygve E.; Miller, Jeremy A.; Smith, Kimberly A.; Barkan, Eliza R.; Graybuck, Lucas T.; Close, Jennie L.; Long, Brian; Johansen, Nelson; Penn, Osnat; Yao, Zizhen; Eggermont, Jeroen; Höllt, Thomas; Levi, Boaz P.; Shehata, Soraya I.; Aevermann, Brian; Beller, Allison; Bertagnolli, Darren; Brouner, Krissy; Casper, Tamara; Cobbs, Charles; Dalley, Rachel; Dee, Nick; Ding, Song-Lin; Ellenbogen, Richard G.; Fong, Olivia; Garren, Emma; Goldy, Jeff; Gwinn, Ryder P.; Hirschstein, Daniel; Keene, C. Dirk; Keshk, Mohamed; Ko, Andrew L.; Lathia, Kanan; Mahfouz, Ahmed; Maltzer, Zoe; McGraw, Medea; Nguyen, Thuc Nghi; Nyhus, Julie; Ojemann, Jeffrey G.; Oldre, Aaron; Parry, Sheana; Reynolds, Shannon; Rimorin, Christine; Shapovalova, Nadiya V.; Somasundaram, Saroja; Szafer, Aaron; Thomsen, Elliot R.; Tieu, Michael; Quon, Gerald; Scheuermann, Richard H.; Yuste, Rafael; Sunkin, Susan M.; Lelieveldt, Boudewijn; Feng, David; Ng, Lydia; Bernard, Amy; Hawrylycz, Michael; Phillips, John W.; Tasic, Bosiljka; Zeng, Hongkui; Jones, Allan R.; Koch, Christof; Lein, Ed S.

Conserved cell types with divergent features in human versus mouse cortex

Rebecca D. Hodge, Trygve E. Bakken, Jeremy A. Miller, Kimberly A. Smith, Eliza R. Barkan, Lucas T. Graybuck, Jennie L. Close, Brian Long, Nelson Johansen, Osnat Penn, Zizhen Yao, Jeroen Eggermont, Thomas Höllt, Boaz P. Levi, Soraya I. Shehata, Brian Aevermann, Allison Beller, Darren Bertagnolli, Krissy Brouner, Tamara Casper, Charles Cobbs, Rachel Dalley, Nick Dee, Song-Lin Ding, Richard G. Ellenbogen, Olivia Fong, Emma Garren, Jeff Goldy, Ryder P. Gwinn, Daniel Hirschstein, C. Dirk Keene, Mohamed Keshk, Andrew L. Ko, Kanan Lathia, Ahmed Mahfouz, Zoe Maltzer, Medea McGraw, Thuc Nghi Nguyen, Julie Nyhus, Jeffrey G. Ojemann, Aaron Oldre, Sheana Parry, Shannon Reynolds, Christine Rimorin, Nadiya V. Shapovalova, Saroja Somasundaram, Aaron Szafer, Elliot R. Thomsen, Michael Tieu, Gerald Quon, Richard H. Scheuermann, Rafael Yuste, Susan M. Sunkin, Boudewijn Lelieveldt, David Feng, Lydia Ng, Amy Bernard, Michael Hawrylycz, John W. Phillips, Bosiljka Tasic, Hongkui Zeng, Allan R. Jones, Christof Koch and Ed S. Lein ()
Additional contact information
Rebecca D. Hodge: Allen Institute for Brain Science
Trygve E. Bakken: Allen Institute for Brain Science
Jeremy A. Miller: Allen Institute for Brain Science
Kimberly A. Smith: Allen Institute for Brain Science
Eliza R. Barkan: Allen Institute for Brain Science
Lucas T. Graybuck: Allen Institute for Brain Science
Jennie L. Close: Allen Institute for Brain Science
Brian Long: Allen Institute for Brain Science
Nelson Johansen: University of California, Davis
Osnat Penn: Allen Institute for Brain Science
Zizhen Yao: Allen Institute for Brain Science
Jeroen Eggermont: Leiden University Medical Center
Thomas Höllt: Leiden University Medical Center
Boaz P. Levi: Allen Institute for Brain Science
Soraya I. Shehata: Allen Institute for Brain Science
Brian Aevermann: J. Craig Venter Institute
Allison Beller: University of Washington
Darren Bertagnolli: Allen Institute for Brain Science
Krissy Brouner: Allen Institute for Brain Science
Tamara Casper: Allen Institute for Brain Science
Charles Cobbs: Swedish Neuroscience Institute
Rachel Dalley: Allen Institute for Brain Science
Nick Dee: Allen Institute for Brain Science
Song-Lin Ding: Allen Institute for Brain Science
Richard G. Ellenbogen: University of Washington School of Medicine
Olivia Fong: Allen Institute for Brain Science
Emma Garren: Allen Institute for Brain Science
Jeff Goldy: Allen Institute for Brain Science
Ryder P. Gwinn: Swedish Neuroscience Institute
Daniel Hirschstein: Allen Institute for Brain Science
C. Dirk Keene: University of Washington
Mohamed Keshk: J. Craig Venter Institute
Andrew L. Ko: University of Washington School of Medicine
Kanan Lathia: Allen Institute for Brain Science
Ahmed Mahfouz: Leiden University Medical Center
Zoe Maltzer: Allen Institute for Brain Science
Medea McGraw: Allen Institute for Brain Science
Thuc Nghi Nguyen: Allen Institute for Brain Science
Julie Nyhus: Allen Institute for Brain Science
Jeffrey G. Ojemann: University of Washington School of Medicine
Aaron Oldre: Allen Institute for Brain Science
Sheana Parry: Allen Institute for Brain Science
Shannon Reynolds: Allen Institute for Brain Science
Christine Rimorin: Allen Institute for Brain Science
Nadiya V. Shapovalova: Allen Institute for Brain Science
Saroja Somasundaram: Allen Institute for Brain Science
Aaron Szafer: Allen Institute for Brain Science
Elliot R. Thomsen: Allen Institute for Brain Science
Michael Tieu: Allen Institute for Brain Science
Gerald Quon: University of California, Davis
Richard H. Scheuermann: J. Craig Venter Institute
Rafael Yuste: Columbia University
Susan M. Sunkin: Allen Institute for Brain Science
Boudewijn Lelieveldt: Leiden University Medical Center
David Feng: Allen Institute for Brain Science
Lydia Ng: Allen Institute for Brain Science
Amy Bernard: Allen Institute for Brain Science
Michael Hawrylycz: Allen Institute for Brain Science
John W. Phillips: Allen Institute for Brain Science
Bosiljka Tasic: Allen Institute for Brain Science
Hongkui Zeng: Allen Institute for Brain Science
Allan R. Jones: Allen Institute for Brain Science
Christof Koch: Allen Institute for Brain Science
Ed S. Lein: Allen Institute for Brain Science

Nature, 2019, vol. 573, issue 7772, 61-68

Abstract: Abstract Elucidating the cellular architecture of the human cerebral cortex is central to understanding our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-sequencing analysis to perform a comprehensive study of cell types in the middle temporal gyrus of human cortex. We identified a highly diverse set of excitatory and inhibitory neuron types that are mostly sparse, with excitatory types being less layer-restricted than expected. Comparison to similar mouse cortex single-cell RNA-sequencing datasets revealed a surprisingly well-conserved cellular architecture that enables matching of homologous types and predictions of properties of human cell types. Despite this general conservation, we also found extensive differences between homologous human and mouse cell types, including marked alterations in proportions, laminar distributions, gene expression and morphology. These species-specific features emphasize the importance of directly studying human brain.

Date: 2019
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DOI: 10.1038/s41586-019-1506-7

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