Temporal plasticity of apical progenitors in the developing mouse neocortex

Polina Oberst, Sabine Fièvre, Natalia Baumann, Cristina Concetti, Giorgia Bartolini and Denis Jabaudon ()
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Polina Oberst: University of Geneva
Sabine Fièvre: University of Geneva
Natalia Baumann: University of Geneva
Cristina Concetti: University of Geneva
Giorgia Bartolini: University of Geneva
Denis Jabaudon: University of Geneva

Nature, 2019, vol. 573, issue 7774, 370-374

Abstract: Abstract The diverse subtypes of excitatory neurons that populate the neocortex are born from apical progenitors located in the ventricular zone. During corticogenesis, apical progenitors sequentially generate deep-layer neurons followed by superficial-layer neurons directly or via the generation of intermediate progenitors. Whether neurogenic fate progression necessarily implies fate restriction in single progenitor types is unknown. Here we specifically isolated apical progenitors and intermediate progenitors, and fate-mapped their respective neuronal progeny following heterochronic transplantation into younger embryos. We find that apical progenitors are temporally plastic and can re-enter past molecular, electrophysiological and neurogenic states when exposed to an earlier-stage environment by sensing dynamic changes in extracellular Wnt. By contrast, intermediate progenitors are committed progenitors that lack such retrograde fate plasticity. These findings identify a diversity in the temporal plasticity of neocortical progenitors, revealing that some subtypes of cells can be untethered from their normal temporal progression to re-enter past developmental states.

Date: 2019
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DOI: 10.1038/s41586-019-1515-6

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