Hierarchical organization of cortical and thalamic connectivity

Julie A. Harris (), Stefan Mihalas, Karla E. Hirokawa, Jennifer D. Whitesell, Hannah Choi, Amy Bernard, Phillip Bohn, Shiella Caldejon, Linzy Casal, Andrew Cho, Aaron Feiner, David Feng, Nathalie Gaudreault, Charles R. Gerfen, Nile Graddis, Peter A. Groblewski, Alex M. Henry, Anh Ho, Robert Howard, Joseph E. Knox, Leonard Kuan, Xiuli Kuang, Jerome Lecoq, Phil Lesnar, Yaoyao Li, Jennifer Luviano, Stephen McConoughey, Marty T. Mortrud, Maitham Naeemi, Lydia Ng, Seung Wook Oh, Benjamin Ouellette, Elise Shen, Staci A. Sorensen, Wayne Wakeman, Quanxin Wang, Yun Wang, Ali Williford, John W. Phillips, Allan R. Jones, Christof Koch and Hongkui Zeng
Additional contact information
Julie A. Harris: Allen Institute for Brain Science
Stefan Mihalas: Allen Institute for Brain Science
Karla E. Hirokawa: Allen Institute for Brain Science
Jennifer D. Whitesell: Allen Institute for Brain Science
Hannah Choi: Allen Institute for Brain Science
Amy Bernard: Allen Institute for Brain Science
Phillip Bohn: Allen Institute for Brain Science
Shiella Caldejon: Allen Institute for Brain Science
Linzy Casal: Allen Institute for Brain Science
Andrew Cho: Allen Institute for Brain Science
Aaron Feiner: Allen Institute for Brain Science
David Feng: Allen Institute for Brain Science
Nathalie Gaudreault: Allen Institute for Brain Science
Charles R. Gerfen: National Institute of Mental Health
Nile Graddis: Allen Institute for Brain Science
Peter A. Groblewski: Allen Institute for Brain Science
Alex M. Henry: Allen Institute for Brain Science
Anh Ho: Allen Institute for Brain Science
Robert Howard: Allen Institute for Brain Science
Joseph E. Knox: Allen Institute for Brain Science
Leonard Kuan: Allen Institute for Brain Science
Xiuli Kuang: Wenzhou Medical University
Jerome Lecoq: Allen Institute for Brain Science
Phil Lesnar: Allen Institute for Brain Science
Yaoyao Li: Wenzhou Medical University
Jennifer Luviano: Allen Institute for Brain Science
Stephen McConoughey: Allen Institute for Brain Science
Marty T. Mortrud: Allen Institute for Brain Science
Maitham Naeemi: Allen Institute for Brain Science
Lydia Ng: Allen Institute for Brain Science
Seung Wook Oh: Allen Institute for Brain Science
Benjamin Ouellette: Allen Institute for Brain Science
Elise Shen: Allen Institute for Brain Science
Staci A. Sorensen: Allen Institute for Brain Science
Wayne Wakeman: Allen Institute for Brain Science
Quanxin Wang: Allen Institute for Brain Science
Yun Wang: Allen Institute for Brain Science
Ali Williford: Allen Institute for Brain Science
John W. Phillips: Allen Institute for Brain Science
Allan R. Jones: Allen Institute for Brain Science
Christof Koch: Allen Institute for Brain Science
Hongkui Zeng: Allen Institute for Brain Science

Nature, 2019, vol. 575, issue 7781, 195-202

Abstract: Abstract The mammalian cortex is a laminar structure containing many areas and cell types that are densely interconnected in complex ways, and for which generalizable principles of organization remain mostly unknown. Here we describe a major expansion of the Allen Mouse Brain Connectivity Atlas resource1, involving around a thousand new tracer experiments in the cortex and its main satellite structure, the thalamus. We used Cre driver lines (mice expressing Cre recombinase) to comprehensively and selectively label brain-wide connections by layer and class of projection neuron. Through observations of axon termination patterns, we have derived a set of generalized anatomical rules to describe corticocortical, thalamocortical and corticothalamic projections. We have built a model to assign connection patterns between areas as either feedforward or feedback, and generated testable predictions of hierarchical positions for individual cortical and thalamic areas and for cortical network modules. Our results show that cell-class-specific connections are organized in a shallow hierarchy within the mouse corticothalamic network.

Date: 2019
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DOI: 10.1038/s41586-019-1716-z

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