Patch repair of deep wounds by mobilized fascia

Donovan Correa-Gallegos, Dongsheng Jiang, Simon Christ, Pushkar Ramesh, Haifeng Ye, Juliane Wannemacher, Shruthi Kalgudde Gopal, Qing Yu, Michaela Aichler, Axel Walch, Ursula Mirastschijski, Thomas Volz and Yuval Rinkevich ()
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Donovan Correa-Gallegos: Institute of Lung Biology and Disease, Helmholtz Zentrum München
Dongsheng Jiang: Institute of Lung Biology and Disease, Helmholtz Zentrum München
Simon Christ: Institute of Lung Biology and Disease, Helmholtz Zentrum München
Pushkar Ramesh: Institute of Lung Biology and Disease, Helmholtz Zentrum München
Haifeng Ye: Institute of Lung Biology and Disease, Helmholtz Zentrum München
Juliane Wannemacher: Institute of Lung Biology and Disease, Helmholtz Zentrum München
Shruthi Kalgudde Gopal: Institute of Lung Biology and Disease, Helmholtz Zentrum München
Qing Yu: Institute of Lung Biology and Disease, Helmholtz Zentrum München
Michaela Aichler: Helmholtz Zentrum München
Axel Walch: Helmholtz Zentrum München
Ursula Mirastschijski: Mira-Beau Gender Esthetics
Thomas Volz: Klinikum rechts der Isar, Technical University of Munich
Yuval Rinkevich: Institute of Lung Biology and Disease, Helmholtz Zentrum München

Nature, 2019, vol. 576, issue 7786, 287-292

Abstract: Abstract Mammals form scars to quickly seal wounds and ensure survival by an incompletely understood mechanism1–5. Here we show that skin scars originate from prefabricated matrix in the subcutaneous fascia. Fate mapping and live imaging revealed that fascia fibroblasts rise to the skin surface after wounding, dragging their surrounding extracellular jelly-like matrix, including embedded blood vessels, macrophages and peripheral nerves, to form the provisional matrix. Genetic ablation of fascia fibroblasts prevented matrix from homing into wounds and resulted in defective scars, whereas placing an impermeable film beneath the skin—preventing fascia fibroblasts from migrating upwards—led to chronic open wounds. Thus, fascia contains a specialized prefabricated kit of sentry fibroblasts, embedded within a movable sealant, that preassemble together diverse cell types and matrix components needed to heal wounds. Our findings suggest that chronic and excessive skin wounds may be attributed to the mobility of the fascia matrix.

Date: 2019
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DOI: 10.1038/s41586-019-1794-y

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