An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

Caroline S. Jansen, Nataliya Prokhnevska, Viraj A. Master, Martin G. Sanda, Jennifer W. Carlisle, Mehmet Asim Bilen, Maria Cardenas, Scott Wilkinson, Ross Lake, Adam G. Sowalsky, Rajesh M. Valanparambil, William H. Hudson, Donald McGuire, Kevin Melnick, Amir I. Khan, Kyu Kim, Yun Min Chang, Alice Kim, Christopher P. Filson, Mehrdad Alemozaffar, Adeboye O. Osunkoya, Patrick Mullane, Carla Ellis, Rama Akondy, Se Jin Im, Alice O. Kamphorst, Adriana Reyes, Yuan Liu and Haydn Kissick ()
Additional contact information
Caroline S. Jansen: Emory University School of Medicine
Nataliya Prokhnevska: Emory University School of Medicine
Viraj A. Master: Emory University School of Medicine
Martin G. Sanda: Emory University School of Medicine
Jennifer W. Carlisle: Winship Cancer Institute of Emory University
Mehmet Asim Bilen: Winship Cancer Institute of Emory University
Maria Cardenas: Emory University School of Medicine
Scott Wilkinson: National Cancer Institute
Ross Lake: National Cancer Institute
Adam G. Sowalsky: National Cancer Institute
Rajesh M. Valanparambil: Emory University School of Medicine
William H. Hudson: Emory University School of Medicine
Donald McGuire: Emory University School of Medicine
Kevin Melnick: Emory University School of Medicine
Amir I. Khan: Emory University School of Medicine
Kyu Kim: Emory University School of Medicine
Yun Min Chang: Emory University School of Medicine
Alice Kim: Emory University School of Medicine
Christopher P. Filson: Emory University School of Medicine
Mehrdad Alemozaffar: Emory University School of Medicine
Adeboye O. Osunkoya: Emory University School of Medicine
Patrick Mullane: Emory University School of Medicine
Carla Ellis: Emory University School of Medicine
Rama Akondy: Emory University School of Medicine
Se Jin Im: Emory University School of Medicine
Alice O. Kamphorst: Icahn School of Medicine at Mount Sinai
Adriana Reyes: Emory University School of Medicine
Yuan Liu: Winship Cancer Institute of Emory University
Haydn Kissick: Emory University School of Medicine

Nature, 2019, vol. 576, issue 7787, 465-470

Abstract: Abstract Tumour-infiltrating lymphocytes are associated with a survival benefit in several tumour types and with the response to immunotherapy1–8. However, the reason some tumours have high CD8 T cell infiltration while others do not remains unclear. Here we investigate the requirements for maintaining a CD8 T cell response against human cancer. We find that CD8 T cells within tumours consist of distinct populations of terminally differentiated and stem-like cells. On proliferation, stem-like CD8 T cells give rise to more terminally differentiated, effector-molecule-expressing daughter cells. For many T cells to infiltrate the tumour, it is critical that this effector differentiation process occur. In addition, we show that these stem-like T cells reside in dense antigen-presenting-cell niches within the tumour, and that tumours that fail to form these structures are not extensively infiltrated by T cells. Patients with progressive disease lack these immune niches, suggesting that niche breakdown may be a key mechanism of immune escape.

Date: 2019
References: Add references at CitEc
Citations: View citations in EconPapers (12)

Downloads: (external link)
https://www.nature.com/articles/s41586-019-1836-5 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:576:y:2019:i:7787:d:10.1038_s41586-019-1836-5

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/s41586-019-1836-5

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().