Why and where an HIV cure is needed and how it might be achieved

Thumbi Ndung’u, Joseph M. McCune and Steven G. Deeks ()
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Thumbi Ndung’u: Africa Health Research Institute
Joseph M. McCune: Bill & Melinda Gates Foundation
Steven G. Deeks: University of California San Francisco

Nature, 2019, vol. 576, issue 7787, 397-405

Abstract: Abstract Despite considerable global investment, only 60% of people who live with HIV currently receive antiretroviral therapy. The sustainability of current programmes remains unknown and key incidence rates are declining only modestly. Given the complexities and expenses associated with lifelong medication, developing an effective curative intervention is now a global priority. Here we review why and where a cure is needed, and how it might be achieved. We argue for expanding these efforts from resource-rich regions to sub-Saharan Africa and elsewhere: for any intervention to have an effect, region-specific biological, therapeutic and implementation issues must be addressed.

Date: 2019
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DOI: 10.1038/s41586-019-1841-8

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