The arms race between bacteria and their phage foes

Hannah G. Hampton, Bridget N. J. Watson and Peter C. Fineran ()
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Hannah G. Hampton: University of Otago
Bridget N. J. Watson: University of Otago
Peter C. Fineran: University of Otago

Nature, 2020, vol. 577, issue 7790, 327-336

Abstract: Abstract Bacteria are under immense evolutionary pressure from their viral invaders—bacteriophages. Bacteria have evolved numerous immune mechanisms, both innate and adaptive, to cope with this pressure. The discovery and exploitation of CRISPR–Cas systems have stimulated a resurgence in the identification and characterization of anti-phage mechanisms. Bacteriophages use an extensive battery of counter-defence strategies to co-exist in the presence of these diverse phage defence mechanisms. Understanding the dynamics of the interactions between these microorganisms has implications for phage-based therapies, microbial ecology and evolution, and the development of new biotechnological tools. Here we review the spectrum of anti-phage systems and highlight their evasion by bacteriophages.

Date: 2020
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DOI: 10.1038/s41586-019-1894-8

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