A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David Ridder, Steffi Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill (), Marc Vidal (), Frederick P. Roth () and Michael A. Calderwood ()
Additional contact information
Katja Luck: Dana-Farber Cancer Institute
Dae-Kyum Kim: Dana-Farber Cancer Institute
Luke Lambourne: Dana-Farber Cancer Institute
Kerstin Spirohn: Dana-Farber Cancer Institute
Bridget E. Begg: Dana-Farber Cancer Institute
Wenting Bian: Dana-Farber Cancer Institute
Ruth Brignall: Dana-Farber Cancer Institute
Tiziana Cafarelli: Dana-Farber Cancer Institute
Francisco J. Campos-Laborie: Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca (USAL)
Benoit Charloteaux: Dana-Farber Cancer Institute
Dongsic Choi: The Research Institute of the McGill University Health Centre (RI-MUHC)
Atina G. Coté: Dana-Farber Cancer Institute
Meaghan Daley: Dana-Farber Cancer Institute
Steven Deimling: University of Toronto
Alice Desbuleux: Dana-Farber Cancer Institute
Amélie Dricot: Dana-Farber Cancer Institute
Marinella Gebbia: Dana-Farber Cancer Institute
Madeleine F. Hardy: Dana-Farber Cancer Institute
Nishka Kishore: Dana-Farber Cancer Institute
Jennifer J. Knapp: Dana-Farber Cancer Institute
István A. Kovács: Dana-Farber Cancer Institute
Irma Lemmens: Vlaams Instituut voor Biotechnologie (VIB)
Miles W. Mee: University of Toronto
Joseph C. Mellor: Dana-Farber Cancer Institute
Carl Pollis: Dana-Farber Cancer Institute
Carles Pons: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology
Aaron D. Richardson: Dana-Farber Cancer Institute
Sadie Schlabach: Dana-Farber Cancer Institute
Bridget Teeking: Dana-Farber Cancer Institute
Anupama Yadav: Dana-Farber Cancer Institute
Mariana Babor: Dana-Farber Cancer Institute
Dawit Balcha: Dana-Farber Cancer Institute
Omer Basha: Ben-Gurion University of the Negev
Christian Bowman-Colin: Harvard Medical School
Suet-Feung Chin: University of Cambridge
Soon Gang Choi: Dana-Farber Cancer Institute
Claudia Colabella: University of Perugia
Georges Coppin: Dana-Farber Cancer Institute
Cassandra D’Amata: University of Toronto
David Ridder: Dana-Farber Cancer Institute
Steffi Rouck: Vlaams Instituut voor Biotechnologie (VIB)
Miquel Duran-Frigola: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology
Hanane Ennajdaoui: Dana-Farber Cancer Institute
Florian Goebels: University of Toronto
Liana Goehring: Harvard Medical School
Anjali Gopal: Dana-Farber Cancer Institute
Ghazal Haddad: Dana-Farber Cancer Institute
Elodie Hatchi: Harvard Medical School
Mohamed Helmy: University of Toronto
Yves Jacob: Département de Virologie, Unité de Génétique Moléculaire des Virus à ARN (GMVR), Institut Pasteur, UMR3569, Centre National de la Recherche Scientifique (CNRS)
Yoseph Kassa: Dana-Farber Cancer Institute
Serena Landini: Harvard Medical School
Roujia Li: Dana-Farber Cancer Institute
Natascha Lieshout: Dana-Farber Cancer Institute
Andrew MacWilliams: Dana-Farber Cancer Institute
Dylan Markey: Dana-Farber Cancer Institute
Joseph N. Paulson: Dana-Farber Cancer Institute
Sudharshan Rangarajan: Dana-Farber Cancer Institute
John Rasla: Dana-Farber Cancer Institute
Ashyad Rayhan: Dana-Farber Cancer Institute
Thomas Rolland: Dana-Farber Cancer Institute
Adriana San-Miguel: Dana-Farber Cancer Institute
Yun Shen: Dana-Farber Cancer Institute
Dayag Sheykhkarimli: Dana-Farber Cancer Institute
Gloria M. Sheynkman: Dana-Farber Cancer Institute
Eyal Simonovsky: Ben-Gurion University of the Negev
Murat Taşan: Dana-Farber Cancer Institute
Alexander Tejeda: Dana-Farber Cancer Institute
Vincent Tropepe: University of Toronto
Jean-Claude Twizere: Groupe Interdisciplinaire de Génomique Appliquée (GIGA) and Laboratory of Viral Interactomes, University of Liège
Yang Wang: Dana-Farber Cancer Institute
Robert J. Weatheritt: University of Toronto
Jochen Weile: Dana-Farber Cancer Institute
Yu Xia: Dana-Farber Cancer Institute
Xinping Yang: Dana-Farber Cancer Institute
Esti Yeger-Lotem: Ben-Gurion University of the Negev
Quan Zhong: Dana-Farber Cancer Institute
Patrick Aloy: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology
Gary D. Bader: University of Toronto
Javier Las Rivas: Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca (USAL)
Suzanne Gaudet: Dana-Farber Cancer Institute
Tong Hao: Dana-Farber Cancer Institute
Janusz Rak: The Research Institute of the McGill University Health Centre (RI-MUHC)
Jan Tavernier: Vlaams Instituut voor Biotechnologie (VIB)
David E. Hill: Dana-Farber Cancer Institute
Marc Vidal: Dana-Farber Cancer Institute
Frederick P. Roth: Dana-Farber Cancer Institute
Michael A. Calderwood: Dana-Farber Cancer Institute

Nature, 2020, vol. 580, issue 7803, 402-408

Abstract: Abstract Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype–phenotype relationships1,2. Here we present a human ‘all-by-all’ reference interactome map of human binary protein interactions, or ‘HuRI’. With approximately 53,000 protein–protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration of HuRI with genome3, transcriptome4 and proteome5 data enables cellular function to be studied within most physiological or pathological cellular contexts. We demonstrate the utility of HuRI in identifying the specific subcellular roles of protein–protein interactions. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases. HuRI is a systematic proteome-wide reference that links genomic variation to phenotypic outcomes.

Date: 2020
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DOI: 10.1038/s41586-020-2188-x

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