Construction of a human cell landscape at single-cell level

Xiaoping Han (), Ziming Zhou, Lijiang Fei, Huiyu Sun, Renying Wang, Yao Chen, Haide Chen, Jingjing Wang, Huanna Tang, Wenhao Ge, Yincong Zhou, Fang Ye, Mengmeng Jiang, Junqing Wu, Yanyu Xiao, Xiaoning Jia, Tingyue Zhang, Xiaojie Ma, Qi Zhang, Xueli Bai, Shujing Lai, Chengxuan Yu, Lijun Zhu, Rui Lin, Yuchi Gao, Min Wang, Yiqing Wu, Jianming Zhang, Renya Zhan, Saiyong Zhu, Hailan Hu, Changchun Wang, Ming Chen, He Huang, Tingbo Liang, Jianghua Chen, Weilin Wang, Dan Zhang and Guoji Guo ()
Additional contact information
Xiaoping Han: Zhejiang University School of Medicine
Ziming Zhou: Zhejiang University School of Medicine
Lijiang Fei: Zhejiang University School of Medicine
Huiyu Sun: Zhejiang University School of Medicine
Renying Wang: Zhejiang University School of Medicine
Yao Chen: Zhejiang University School of Medicine
Haide Chen: Zhejiang University School of Medicine
Jingjing Wang: Zhejiang University School of Medicine
Huanna Tang: Zhejiang University School of Medicine
Wenhao Ge: Zhejiang University School of Medicine
Yincong Zhou: Zhejiang University
Fang Ye: Zhejiang University School of Medicine
Mengmeng Jiang: Zhejiang University School of Medicine
Junqing Wu: Zhejiang University School of Medicine
Yanyu Xiao: Zhejiang University School of Medicine
Xiaoning Jia: Zhejiang University School of Medicine
Tingyue Zhang: Zhejiang University School of Medicine
Xiaojie Ma: Zhejiang University
Qi Zhang: Zhejiang University School of Medicine
Xueli Bai: Zhejiang University School of Medicine
Shujing Lai: Zhejiang University School of Medicine
Chengxuan Yu: Zhejiang University School of Medicine
Lijun Zhu: Zhejiang University School of Medicine
Rui Lin: Hangzhou Repugene Technology
Yuchi Gao: Annoroad Gene Technology
Min Wang: Veritas Genetics Asia
Yiqing Wu: Zhejiang University School of Medicine
Jianming Zhang: Zhejiang University School of Medicine
Renya Zhan: Zhejiang University School of Medicine
Saiyong Zhu: Zhejiang University
Hailan Hu: Zhejiang University School of Medicine
Changchun Wang: Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital
Ming Chen: Zhejiang University
He Huang: Zhejiang University School of Medicine
Tingbo Liang: Zhejiang University School of Medicine
Jianghua Chen: Zhejiang University School of Medicine
Weilin Wang: Zhejiang University School of Medicine
Dan Zhang: Zhejiang University School of Medicine
Guoji Guo: Zhejiang University School of Medicine

Nature, 2020, vol. 581, issue 7808, 303-309

Abstract: Abstract Single-cell analysis is a valuable tool for dissecting cellular heterogeneity in complex systems1. However, a comprehensive single-cell atlas has not been achieved for humans. Here we use single-cell mRNA sequencing to determine the cell-type composition of all major human organs and construct a scheme for the human cell landscape (HCL). We have uncovered a single-cell hierarchy for many tissues that have not been well characterized. We established a ‘single-cell HCL analysis’ pipeline that helps to define human cell identity. Finally, we performed a single-cell comparative analysis of landscapes from human and mouse to identify conserved genetic networks. We found that stem and progenitor cells exhibit strong transcriptomic stochasticity, whereas differentiated cells are more distinct. Our results provide a useful resource for the study of human biology.

Date: 2020
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DOI: 10.1038/s41586-020-2157-4

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