Identification of type 2 diabetes loci in 433,540 East Asian individuals

Cassandra N. Spracklen, Momoko Horikoshi, Young Jin Kim, Kuang Lin, Fiona Bragg, Sanghoon Moon, Ken Suzuki, Claudia H. T. Tam, Yasuharu Tabara, Soo-Heon Kwak, Fumihiko Takeuchi, Jirong Long, Victor J. Y. Lim, Jin-Fang Chai, Chien-Hsiun Chen, Masahiro Nakatochi, Jie Yao, Hyeok Sun Choi, Apoorva K. Iyengar, Hannah J. Perrin, Sarah M. Brotman, Martijn van de Bunt, Anna L. Gloyn, Jennifer E. Below, Michael Boehnke, Donald W. Bowden, John C. Chambers, Anubha Mahajan, Mark I. McCarthy, Maggie C. Y. Ng, Lauren E. Petty, Weihua Zhang, Andrew P. Morris, Linda S. Adair, Masato Akiyama, Zheng Bian, Juliana C. N. Chan, Li-Ching Chang, Miao-Li Chee, Yii- Der Ida Chen, Yuan-Tsong Chen, Zhengming Chen, Lee-Ming Chuang, Shufa Du, Penny Gordon-Larsen, Myron Gross, Xiuqing Guo, Yu Guo, Sohee Han, Annie-Green Howard, Wei Huang, Yi-Jen Hung, Mi Yeong Hwang, Chii-Min Hwu, Sahoko Ichihara, Masato Isono, Hye-Mi Jang, Guozhi Jiang, Jost B. Jonas, Yoichiro Kamatani, Tomohiro Katsuya, Takahisa Kawaguchi, Chiea-Chuen Khor, Katsuhiko Kohara, Myung-Shik Lee, Nanette R. Lee, Liming Li, Jianjun Liu, Andrea O. Luk, Jun Lv, Yukinori Okada, Mark A. Pereira, Charumathi Sabanayagam, Jinxiu Shi, Dong Mun Shin, Wing Yee So, Atsushi Takahashi, Brian Tomlinson, Fuu-Jen Tsai, Rob M. van Dam, Yong-Bing Xiang, Ken Yamamoto, Toshimasa Yamauchi, Kyungheon Yoon, Canqing Yu, Jian-Min Yuan, Liang Zhang, Wei Zheng, Michiya Igase, Yoon Shin Cho, Jerome I. Rotter, Ya-Xing Wang, Wayne H. H. Sheu, Mitsuhiro Yokota, Jer-Yuarn Wu, Ching-Yu Cheng, Tien-Yin Wong, Xiao-Ou Shu, Norihiro Kato, Kyong-Soo Park, E-Shyong Tai, Fumihiko Matsuda, Woon-Puay Koh, Ronald C. W. Ma, Shiro Maeda, Iona Y. Millwood, Juyoung Lee, Takashi Kadowaki (), Robin G. Walters (), Bong-Jo Kim (), Karen L. Mohlke () and Xueling Sim ()
Additional contact information
Cassandra N. Spracklen: University of North Carolina at Chapel Hill
Momoko Horikoshi: RIKEN Centre for Integrative Medical Sciences
Young Jin Kim: National Institute of Health
Kuang Lin: University of Oxford
Fiona Bragg: University of Oxford
Sanghoon Moon: National Institute of Health
Ken Suzuki: RIKEN Centre for Integrative Medical Sciences
Claudia H. T. Tam: The Chinese University of Hong Kong
Yasuharu Tabara: Kyoto University Graduate School of Medicine
Soo-Heon Kwak: Seoul National University Hospital
Fumihiko Takeuchi: National Center for Global Health and Medicine
Jirong Long: Vanderbilt University Medical Center
Victor J. Y. Lim: National University of Singapore and National University Health System
Jin-Fang Chai: National University of Singapore and National University Health System
Chien-Hsiun Chen: Academia Sinica
Masahiro Nakatochi: Nagoya University Graduate School of Medicine
Jie Yao: The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Hyeok Sun Choi: Hallym University
Apoorva K. Iyengar: University of North Carolina at Chapel Hill
Hannah J. Perrin: University of North Carolina at Chapel Hill
Sarah M. Brotman: University of North Carolina at Chapel Hill
Martijn van de Bunt: University of Oxford
Anna L. Gloyn: University of Oxford
Jennifer E. Below: Vanderbilt University Medical Center
Michael Boehnke: University of Michigan
Donald W. Bowden: Wake Forest School of Medicine
John C. Chambers: Nanyang Technological University
Anubha Mahajan: University of Oxford
Mark I. McCarthy: University of Oxford
Maggie C. Y. Ng: Vanderbilt University Medical Center
Lauren E. Petty: Vanderbilt University Medical Center
Weihua Zhang: Imperial College London
Andrew P. Morris: University of Oxford
Linda S. Adair: University of North Carolina at Chapel Hill
Masato Akiyama: RIKEN Centre for Integrative Medical Sciences
Zheng Bian: Chinese Academy of Medical Sciences
Juliana C. N. Chan: The Chinese University of Hong Kong
Li-Ching Chang: Academia Sinica
Miao-Li Chee: Singapore National Eye Centre
Yii- Der Ida Chen: The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Yuan-Tsong Chen: Academia Sinica
Zhengming Chen: University of Oxford
Lee-Ming Chuang: National Taiwan University Hospital
Shufa Du: University of North Carolina at Chapel Hill
Penny Gordon-Larsen: University of North Carolina at Chapel Hill
Myron Gross: University of Minnesota
Xiuqing Guo: The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Yu Guo: Chinese Academy of Medical Sciences
Sohee Han: National Institute of Health
Annie-Green Howard: University of North Carolina at Chapel Hill
Wei Huang: Chinese National Human Genome Center at Shanghai
Yi-Jen Hung: Tri-Service General Hospital Songshan Branch
Mi Yeong Hwang: National Institute of Health
Chii-Min Hwu: Taipei Veterans General Hospital
Sahoko Ichihara: Jichi Medical University School of Medicine
Masato Isono: National Center for Global Health and Medicine
Hye-Mi Jang: National Institute of Health
Guozhi Jiang: The Chinese University of Hong Kong
Jost B. Jonas: Medical Faculty Mannheim of the University of Heidelberg
Yoichiro Kamatani: RIKEN Centre for Integrative Medical Sciences
Tomohiro Katsuya: Osaka University Graduate School of Medicine
Takahisa Kawaguchi: Kyoto University Graduate School of Medicine
Chiea-Chuen Khor: Singapore National Eye Centre
Katsuhiko Kohara: Ehime University Faculty of Collaborative Regional Innovation
Myung-Shik Lee: Yonsei University College of Medicine
Nanette R. Lee: University of San Carlos
Liming Li: Peking University
Jianjun Liu: Technology and Research
Andrea O. Luk: The Chinese University of Hong Kong
Jun Lv: Peking University
Yukinori Okada: Osaka University Graduate School of Medicine
Mark A. Pereira: University of Minnesota
Charumathi Sabanayagam: Singapore National Eye Centre
Jinxiu Shi: University of Minnesota
Dong Mun Shin: National Institute of Health
Wing Yee So: The Chinese University of Hong Kong
Atsushi Takahashi: RIKEN Centre for Integrative Medical Sciences
Brian Tomlinson: The Chinese University of Hong Kong
Fuu-Jen Tsai: China Medical University Hospital
Rob M. van Dam: National University of Singapore and National University Health System
Yong-Bing Xiang: Shanghai Jiaotong University School of Medicine
Ken Yamamoto: Kurume University School of Medicine
Toshimasa Yamauchi: The University of Tokyo
Kyungheon Yoon: National Institute of Health
Canqing Yu: Peking University
Jian-Min Yuan: University of Pittsburgh
Liang Zhang: Singapore National Eye Centre
Wei Zheng: Vanderbilt University Medical Center
Michiya Igase: Ehime University Graduate School of Medicine
Yoon Shin Cho: Hallym University
Jerome I. Rotter: The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Ya-Xing Wang: Capital Medical University
Wayne H. H. Sheu: National Defense Medical Center
Mitsuhiro Yokota: Kurume University School of Medicine
Jer-Yuarn Wu: Academia Sinica
Ching-Yu Cheng: Singapore National Eye Centre
Tien-Yin Wong: Singapore National Eye Centre
Xiao-Ou Shu: Vanderbilt University Medical Center
Norihiro Kato: National Center for Global Health and Medicine
Kyong-Soo Park: Seoul National University Hospital
E-Shyong Tai: National University of Singapore and National University Health System
Fumihiko Matsuda: Kyoto University Graduate School of Medicine
Woon-Puay Koh: National University of Singapore and National University Health System
Ronald C. W. Ma: The Chinese University of Hong Kong
Shiro Maeda: RIKEN Centre for Integrative Medical Sciences
Iona Y. Millwood: University of Oxford
Juyoung Lee: National Institute of Health
Takashi Kadowaki: The University of Tokyo
Robin G. Walters: University of Oxford
Bong-Jo Kim: National Institute of Health
Karen L. Mohlke: University of North Carolina at Chapel Hill
Xueling Sim: National University of Singapore and National University Health System

Nature, 2020, vol. 582, issue 7811, 240-245

Abstract: Abstract Meta-analyses of genome-wide association studies (GWAS) have identified more than 240 loci that are associated with type 2 diabetes (T2D)1,2; however, most of these loci have been identified in analyses of individuals with European ancestry. Here, to examine T2D risk in East Asian individuals, we carried out a meta-analysis of GWAS data from 77,418 individuals with T2D and 356,122 healthy control individuals. In the main analysis, we identified 301 distinct association signals at 183 loci, and across T2D association models with and without consideration of body mass index and sex, we identified 61 loci that are newly implicated in predisposition to T2D. Common variants associated with T2D in both East Asian and European populations exhibited strongly correlated effect sizes. Previously undescribed associations include signals in or near GDAP1, PTF1A, SIX3, ALDH2, a microRNA cluster, and genes that affect the differentiation of muscle and adipose cells3. At another locus, expression quantitative trait loci at two overlapping T2D signals affect two genes—NKX6-3 and ANK1—in different tissues4–6. Association studies in diverse populations identify additional loci and elucidate disease-associated genes, biology, and pathways.

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (6)

Downloads: (external link)
https://www.nature.com/articles/s41586-020-2263-3 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:582:y:2020:i:7811:d:10.1038_s41586-020-2263-3

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/s41586-020-2263-3

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().