Basement membrane remodelling regulates mouse embryogenesis

Christos Kyprianou, Neophytos Christodoulou, Russell S. Hamilton, Wallis Nahaboo, Diana Suarez Boomgaard, Gianluca Amadei, Isabelle Migeotte and Magdalena Zernicka-Goetz ()
Additional contact information
Christos Kyprianou: University of Cambridge
Neophytos Christodoulou: University of Cambridge
Russell S. Hamilton: University of Cambridge
Wallis Nahaboo: IRIBHM, Université Libre de Bruxelles
Diana Suarez Boomgaard: IRIBHM, Université Libre de Bruxelles
Gianluca Amadei: University of Cambridge
Isabelle Migeotte: IRIBHM, Université Libre de Bruxelles
Magdalena Zernicka-Goetz: University of Cambridge

Nature, 2020, vol. 582, issue 7811, 253-258

Abstract: Abstract Tissue sculpting during development has been attributed mainly to cellular events through processes such as convergent extension or apical constriction1,2. However, recent work has revealed roles for basement membrane remodelling in global tissue morphogenesis3–5. Upon implantation, the epiblast and extraembryonic ectoderm of the mouse embryo become enveloped by a basement membrane. Signalling between the basement membrane and these tissues is critical for cell polarization and the ensuing morphogenesis6,7. However, the mechanical role of the basement membrane in post-implantation embryogenesis remains unknown. Here we demonstrate the importance of spatiotemporally regulated basement membrane remodelling during early embryonic development. Specifically, we show that Nodal signalling directs the generation and dynamic distribution of perforations in the basement membrane by regulating the expression of matrix metalloproteinases. This basement membrane remodelling facilitates embryo growth before gastrulation. The establishment of the anterior–posterior axis8,9 further regulates basement membrane remodelling by localizing Nodal signalling—and therefore the activity of matrix metalloproteinases and basement membrane perforations—to the posterior side of the embryo. Perforations on the posterior side are essential for primitive-streak extension during gastrulation by rendering the basement membrane of the prospective primitive streak more prone to breaching. Thus spatiotemporally regulated basement membrane remodelling contributes to the coordination of embryo growth, morphogenesis and gastrulation.

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/s41586-020-2264-2 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:582:y:2020:i:7811:d:10.1038_s41586-020-2264-2

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/s41586-020-2264-2

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().