Perspectives on ENCODE

Michael P. Snyder (), Thomas R. Gingeras, Jill E. Moore, Zhiping Weng, Mark B. Gerstein, Bing Ren, Ross C. Hardison, John A. Stamatoyannopoulos, Brenton R. Graveley, Elise A. Feingold, Michael J. Pazin, Michael Pagan, Daniel A. Gilchrist, Benjamin C. Hitz, J. Michael Cherry, Bradley E. Bernstein, Eric M. Mendenhall, Daniel R. Zerbino, Adam Frankish, Paul Flicek and Richard M. Myers
Additional contact information
Michael P. Snyder: Stanford University
Thomas R. Gingeras: Cold Spring Harbor Laboratory
Jill E. Moore: University of Massachusetts Medical School, Program in Bioinformatics and Integrative Biology
Zhiping Weng: University of Massachusetts Medical School, Program in Bioinformatics and Integrative Biology
Mark B. Gerstein: Yale University
Bing Ren: University of California, San Diego
Ross C. Hardison: The Pennsylvania State University
John A. Stamatoyannopoulos: Altius Institute for Biomedical Sciences
Brenton R. Graveley: Institute for Systems Genomics, UConn Health
Elise A. Feingold: National Institutes of Health
Michael J. Pazin: National Institutes of Health
Michael Pagan: National Institutes of Health
Daniel A. Gilchrist: National Institutes of Health
Benjamin C. Hitz: Stanford University
J. Michael Cherry: Stanford University
Bradley E. Bernstein: Massachusetts General Hospital and Harvard Medical School
Eric M. Mendenhall: University of Alabama in Huntsville
Daniel R. Zerbino: European Bioinformatics Institute, Wellcome Genome Campus
Adam Frankish: European Bioinformatics Institute, Wellcome Genome Campus
Paul Flicek: European Bioinformatics Institute, Wellcome Genome Campus
Richard M. Myers: HudsonAlpha Institute for Biotechnology

Nature, 2020, vol. 583, issue 7818, 693-698

Abstract: Abstract The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression1. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community.

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41586-020-2449-8 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:583:y:2020:i:7818:d:10.1038_s41586-020-2449-8

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/s41586-020-2449-8

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().