Modular synthesis enables molecular ju-jitsu in the fight against antibiotic resistance

Daniel J. Blair and Martin D. Burke ()

Nature, 2020, vol. 586, issue 7827, 32-33

Abstract: An ancient resistance mechanism poses a problem when using streptogramin antibiotics. A modular approach to drug synthesis exploits this same mechanism to generate an antibiotic that avoids the emergence of resistance.

Keywords: Synthesis; Organic chemistry; Drug discovery; Structural biology (search for similar items in EconPapers)
Date: 2020
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DOI: 10.1038/d41586-020-02565-1

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