Animal models for COVID-19

César Muñoz-Fontela, William E. Dowling, Simon G. P. Funnell, Pierre-S. Gsell, A. Ximena Riveros-Balta, Randy A. Albrecht, Hanne Andersen, Ralph S. Baric, Miles W. Carroll, Marco Cavaleri, Chuan Qin, Ian Crozier, Kai Dallmeier, Leon Waal, Emmie Wit, Leen Delang, Erik Dohm, W. Paul Duprex, Darryl Falzarano, Courtney L. Finch, Matthew B. Frieman, Barney S. Graham, Lisa E. Gralinski, Kate Guilfoyle, Bart L. Haagmans, Geraldine A. Hamilton, Amy L. Hartman, Sander Herfst, Suzanne J. F. Kaptein, William B. Klimstra, Ivana Knezevic, Philip R. Krause, Jens H. Kuhn, Roger Grand, Mark G. Lewis, Wen-Chun Liu, Pauline Maisonnasse, Anita K. McElroy, Vincent Munster, Nadia Oreshkova, Angela L. Rasmussen, Joana Rocha-Pereira, Barry Rockx, Estefanía Rodríguez, Thomas F. Rogers, Francisco J. Salguero, Michael Schotsaert, Koert J. Stittelaar, Hendrik Jan Thibaut, Chien-Te Tseng, Júlia Vergara-Alert, Martin Beer, Trevor Brasel, Jasper F. W. Chan, Adolfo García-Sastre, Johan Neyts, Stanley Perlman, Douglas S. Reed, Juergen A. Richt, Chad J. Roy, Joaquim Segalés, Seshadri S. Vasan, Ana María Henao-Restrepo () and Dan H. Barouch ()
Additional contact information
César Muñoz-Fontela: Bernhard Nocht Institute for Tropical Medicine
William E. Dowling: Centre for Epidemic Preparedness Innovations (CEPI)
Simon G. P. Funnell: National Infection Service, Public Health England
Pierre-S. Gsell: World Health Organization
A. Ximena Riveros-Balta: World Health Organization
Randy A. Albrecht: Icahn School of Medicine at Mount Sinai
Hanne Andersen: Bioqual Inc
Ralph S. Baric: University of North Carolina at Chapel Hill
Miles W. Carroll: National Infection Service, Public Health England
Marco Cavaleri: European Medicines Agency
Chuan Qin: Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College
Ian Crozier: Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research
Kai Dallmeier: Rega Institute, Laboratory of Virology and Chemotherapy
Leon Waal: Viroclinics Xplore
Emmie Wit: National Institutes of Health
Leen Delang: Rega Institute, Laboratory of Virology and Chemotherapy
Erik Dohm: University of Alabama at Birmingham
W. Paul Duprex: University of Pittsburgh
Darryl Falzarano: University of Saskatchewan
Courtney L. Finch: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Matthew B. Frieman: University of Maryland School of Medicine
Barney S. Graham: National Institutes of Health
Lisa E. Gralinski: University of North Carolina at Chapel Hill
Kate Guilfoyle: Viroclinics Xplore
Bart L. Haagmans: Erasmus University Medical Center
Geraldine A. Hamilton: Emulate Inc
Amy L. Hartman: University of Pittsburgh
Sander Herfst: Erasmus University Medical Center
Suzanne J. F. Kaptein: Rega Institute, Laboratory of Virology and Chemotherapy
William B. Klimstra: University of Pittsburgh
Ivana Knezevic: World Health Organization
Philip R. Krause: Center for Biologics Evaluation and Research, FDA
Jens H. Kuhn: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Roger Grand: Université Paris-Saclay
Mark G. Lewis: Bioqual Inc
Wen-Chun Liu: Icahn School of Medicine at Mount Sinai
Pauline Maisonnasse: Université Paris-Saclay
Anita K. McElroy: University of Pittsburgh School of Medicine
Vincent Munster: National Institutes of Health
Nadia Oreshkova: Wageningen University and Research
Angela L. Rasmussen: Columbia Mailman |School of Public Health
Joana Rocha-Pereira: Rega Institute, Laboratory of Virology and Chemotherapy
Barry Rockx: Erasmus University Medical Center
Estefanía Rodríguez: Bernhard Nocht Institute for Tropical Medicine
Thomas F. Rogers: University of California San Diego
Francisco J. Salguero: National Infection Service, Public Health England
Michael Schotsaert: Icahn School of Medicine at Mount Sinai
Koert J. Stittelaar: Viroclinics Xplore
Hendrik Jan Thibaut: Rega Institute, Laboratory of Virology and Chemotherapy
Chien-Te Tseng: University of Texas Medical Branch
Júlia Vergara-Alert: Campus Universitat Autònoma de Barcelona
Martin Beer: Institute of Diagnostic Virology, Friedrich-Loeffler-Institut
Trevor Brasel: University of Texas Medical Branch
Jasper F. W. Chan: The University of Hong Kong
Adolfo García-Sastre: Icahn School of Medicine at Mount Sinai
Johan Neyts: Rega Institute, Laboratory of Virology and Chemotherapy
Stanley Perlman: University of Iowa
Douglas S. Reed: University of Pittsburgh
Juergen A. Richt: Kansas State University
Chad J. Roy: Tulane National Primate Research Center
Joaquim Segalés: Campus Universitat Autònoma de Barcelona
Seshadri S. Vasan: Australian Centre for Disease Preparedness, CSIRO, Geelong
Ana María Henao-Restrepo: World Health Organization
Dan H. Barouch: Harvard Medical School

Nature, 2020, vol. 586, issue 7830, 509-515

Abstract: Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.

Date: 2020
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DOI: 10.1038/s41586-020-2787-6

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