Strategic vision for improving human health at The Forefront of Genomics

Eric D. Green (), Chris Gunter, Leslie G. Biesecker, Valentina Francesco, Carla L. Easter, Elise A. Feingold, Adam L. Felsenfeld, David J. Kaufman, Elaine A. Ostrander, William J. Pavan, Adam M. Phillippy, Anastasia L. Wise, Jyoti Gupta Dayal, Britny J. Kish, Allison Mandich, Christopher R. Wellington, Kris A. Wetterstrand, Sarah A. Bates, Darryl Leja, Susan Vasquez, William A. Gahl, Bettie J. Graham, Daniel L. Kastner, Paul Liu, Laura Lyman Rodriguez, Benjamin D. Solomon, Vence L. Bonham, Lawrence C. Brody, Carolyn M. Hutter and Teri A. Manolio
Additional contact information
Eric D. Green: National Institutes of Health
Chris Gunter: National Institutes of Health
Leslie G. Biesecker: National Institutes of Health
Valentina Francesco: National Institutes of Health
Carla L. Easter: National Institutes of Health
Elise A. Feingold: National Institutes of Health
Adam L. Felsenfeld: National Institutes of Health
David J. Kaufman: National Institutes of Health
Elaine A. Ostrander: National Institutes of Health
William J. Pavan: National Institutes of Health
Adam M. Phillippy: National Institutes of Health
Anastasia L. Wise: National Institutes of Health
Jyoti Gupta Dayal: National Institutes of Health
Britny J. Kish: National Institutes of Health
Allison Mandich: National Institutes of Health
Christopher R. Wellington: National Institutes of Health
Kris A. Wetterstrand: National Institutes of Health
Sarah A. Bates: National Institutes of Health
Darryl Leja: National Institutes of Health
Susan Vasquez: National Institutes of Health
William A. Gahl: National Institutes of Health
Bettie J. Graham: National Institutes of Health
Daniel L. Kastner: National Institutes of Health
Paul Liu: National Institutes of Health
Laura Lyman Rodriguez: National Institutes of Health
Benjamin D. Solomon: National Institutes of Health
Vence L. Bonham: National Institutes of Health
Lawrence C. Brody: National Institutes of Health
Carolyn M. Hutter: National Institutes of Health
Teri A. Manolio: National Institutes of Health

Nature, 2020, vol. 586, issue 7831, 683-692

Abstract: Abstract Starting with the launch of the Human Genome Project three decades ago, and continuing after its completion in 2003, genomics has progressively come to have a central and catalytic role in basic and translational research. In addition, studies increasingly demonstrate how genomic information can be effectively used in clinical care. In the future, the anticipated advances in technology development, biological insights, and clinical applications (among others) will lead to more widespread integration of genomics into almost all areas of biomedical research, the adoption of genomics into mainstream medical and public-health practices, and an increasing relevance of genomics for everyday life. On behalf of the research community, the National Human Genome Research Institute recently completed a multi-year process of strategic engagement to identify future research priorities and opportunities in human genomics, with an emphasis on health applications. Here we describe the highest-priority elements envisioned for the cutting-edge of human genomics going forward—that is, at ‘The Forefront of Genomics’.

Date: 2020
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DOI: 10.1038/s41586-020-2817-4

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