LifeTime and improving European healthcare through cell-based interceptive medicine

Nikolaus Rajewsky (), Geneviève Almouzni (), Stanislaw A. Gorski (), Stein Aerts, Ido Amit, Michela G. Bertero, Christoph Bock, Annelien L. Bredenoord, Giacomo Cavalli, Susanna Chiocca, Hans Clevers, Bart De Strooper, Angelika Eggert, Jan Ellenberg, Xosé M. Fernández, Marek Figlerowicz, Susan M. Gasser, Norbert Hubner, Jørgen Kjems, Jürgen A. Knoblich, Grietje Krabbe, Peter Lichter, Sten Linnarsson, Jean-Christophe Marine, John C. Marioni, Marc A. Marti-Renom, Mihai G. Netea, Dörthe Nickel, Marcelo Nollmann, Halina R. Novak, Helen Parkinson, Stefano Piccolo, Inês Pinheiro, Ana Pombo, Christian Popp, Wolf Reik, Sergio Roman-Roman, Philip Rosenstiel, Joachim L. Schultze, Oliver Stegle, Amos Tanay, Giuseppe Testa, Dimitris Thanos, Fabian J. Theis, Maria-Elena Torres-Padilla, Alfonso Valencia, Céline Vallot, Alexander van Oudenaarden, Marie Vidal and Thierry Voet
Additional contact information
Nikolaus Rajewsky: Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Geneviève Almouzni: PSL Research University, Sorbonne Université, Nuclear Dynamics Unit, Equipe Labellisée Ligue contre le cancer
Stanislaw A. Gorski: Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Stein Aerts: VIB Center for Brain and Disease Research
Ido Amit: Weizmann Institute of Science
Michela G. Bertero: Barcelona Institute of Science and Technology
Christoph Bock: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Annelien L. Bredenoord: University Medical Center Utrecht
Giacomo Cavalli: Institute of Human Genetics, UMR 9002, CNRS and University of Montpellier
Susanna Chiocca: IEO, European Institute of Oncology IRCCS
Hans Clevers: Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW)
Bart De Strooper: VIB Center for Brain and Disease Research
Angelika Eggert: Berlin Institute of Health (BIH)
Jan Ellenberg: European Molecular Biology Laboratory
Xosé M. Fernández: Institut Curie, PSL Research University
Marek Figlerowicz: Polish Academy of Sciences
Susan M. Gasser: Friedrich Miescher Institute for Biomedical Research
Norbert Hubner: Charité-Universitätsmedizin
Jørgen Kjems: Aarhus University
Jürgen A. Knoblich: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)
Grietje Krabbe: Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Peter Lichter: German Cancer Research Center (DKFZ)
Sten Linnarsson: Karolinska Institutet
Jean-Christophe Marine: Laboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, KU Leuven
John C. Marioni: European Bioinformatics Institute, Wellcome Genome Campus
Marc A. Marti-Renom: Barcelona Institute of Science and Technology
Mihai G. Netea: Radboud University Medical Center
Dörthe Nickel: Institut Curie, PSL Research University
Marcelo Nollmann: Centre de Biochimie Structurale, CNRS UMR 5048, INSERM U1054, Université de Montpellier
Halina R. Novak: VIB Technology Watch
Helen Parkinson: European Bioinformatics Institute, Wellcome Genome Campus
Stefano Piccolo: University of Padua School of Medicine
Inês Pinheiro: PSL Research University, Sorbonne Université, Nuclear Dynamics Unit, Equipe Labellisée Ligue contre le cancer
Ana Pombo: Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Christian Popp: Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Wolf Reik: Wellcome Sanger Institute, Wellcome Genome Campus
Sergio Roman-Roman: Institut Curie, PSL Research University
Philip Rosenstiel: Institute of Clinical Molecular Biology, Kiel University
Joachim L. Schultze: University of Bonn
Oliver Stegle: European Bioinformatics Institute, Wellcome Genome Campus
Amos Tanay: Weizmann Institute of Science
Giuseppe Testa: IEO, European Institute of Oncology IRCCS
Dimitris Thanos: Academy of Athens
Fabian J. Theis: Institute of Computational Biology, Helmholtz Zentrum München - German Research Center for Environmental Health
Maria-Elena Torres-Padilla: Helmholtz Zentrum München - German Research Center for Environmental Health
Alfonso Valencia: ICREA
Céline Vallot: Institut Curie, PSL Research University
Alexander van Oudenaarden: Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW)
Marie Vidal: Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Thierry Voet: KU Leuven

Nature, 2020, vol. 587, issue 7834, 377-386

Abstract: Abstract Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during the progression from health to disease. The analysis of large molecular and clinical datasets will identify molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. The timely detection and interception of disease embedded in an ethical and patient-centred vision will be achieved through interactions across academia, hospitals, patient associations, health data management systems and industry. The application of this strategy to key medical challenges in cancer, neurological and neuropsychiatric disorders, and infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.

Date: 2020
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DOI: 10.1038/s41586-020-2715-9

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