Fibrosis: from mechanisms to medicines

Neil C. Henderson, Florian Rieder and Thomas A. Wynn ()
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Neil C. Henderson: University of Edinburgh Centre for Inflammation Research, The Queen’s Medical Research Institute, Edinburgh BioQuarter
Florian Rieder: Lerner Research Institute, Cleveland Clinic Foundation
Thomas A. Wynn: Inflammation & Immunology Research Unit, Pfizer Worldwide Research, Development & Medical

Nature, 2020, vol. 587, issue 7835, 555-566

Abstract: Abstract Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the industrialized world. It has long been thought to be relentlessly progressive and irreversible, but both preclinical models and clinical trials in various organ systems have shown that fibrosis is a highly dynamic process. This has clear implications for therapeutic interventions that are designed to capitalize on this inherent plasticity. However, despite substantial progress in our understanding of the pathobiology of fibrosis, a translational gap remains between the identification of putative antifibrotic targets and conversion of this knowledge into effective treatments in humans. Here we discuss the transformative experimental strategies that are being leveraged to dissect the key cellular and molecular mechanisms that regulate fibrosis, and the translational approaches that are enabling the emergence of precision medicine-based therapies for patients with fibrosis.

Date: 2020
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DOI: 10.1038/s41586-020-2938-9

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