SLC25A51 is a mammalian mitochondrial NAD+ transporter

Timothy S. Luongo, Jared M. Eller, Mu-Jie Lu, Marc Niere, Fabio Raith, Caroline Perry, Marc R. Bornstein, Paul Oliphint, Lin Wang, Melanie R. McReynolds, Marie E. Migaud, Joshua D. Rabinowitz, F. Brad Johnson, Kai Johnsson, Mathias Ziegler, Xiaolu A. Cambronne () and Joseph A. Baur ()
Additional contact information
Timothy S. Luongo: University of Pennsylvania
Jared M. Eller: University of Texas at Austin
Mu-Jie Lu: University of Texas at Austin
Marc Niere: University of Bergen
Fabio Raith: Max Planck Institute for Medical Research
Caroline Perry: University of Pennsylvania
Marc R. Bornstein: University of Pennsylvania
Paul Oliphint: University of Texas at Austin
Lin Wang: Princeton University
Melanie R. McReynolds: Princeton University
Marie E. Migaud: University of South Alabama
Joshua D. Rabinowitz: Princeton University
F. Brad Johnson: University of Pennsylvania
Kai Johnsson: Max Planck Institute for Medical Research
Mathias Ziegler: University of Bergen
Xiaolu A. Cambronne: University of Texas at Austin
Joseph A. Baur: University of Pennsylvania

Nature, 2020, vol. 588, issue 7836, 174-179

Abstract: Abstract Mitochondria require nicotinamide adenine dinucleotide (NAD+) to carry out the fundamental processes that fuel respiration and mediate cellular energy transduction. Mitochondrial NAD+ transporters have been identified in yeast and plants1,2, but their existence in mammals remains controversial3–5. Here we demonstrate that mammalian mitochondria can take up intact NAD+, and identify SLC25A51 (also known as MCART1)—an essential6,7 mitochondrial protein of previously unknown function—as a mammalian mitochondrial NAD+ transporter. Loss of SLC25A51 decreases mitochondrial—but not whole-cell—NAD+ content, impairs mitochondrial respiration, and blocks the uptake of NAD+ into isolated mitochondria. Conversely, overexpression of SLC25A51 or SLC25A52 (a nearly identical paralogue of SLC25A51) increases mitochondrial NAD+ levels and restores NAD+ uptake into yeast mitochondria lacking endogenous NAD+ transporters. Together, these findings identify SLC25A51 as a mammalian transporter capable of importing NAD+ into mitochondria.

Date: 2020
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DOI: 10.1038/s41586-020-2741-7

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