Cells of the adult human heart

Monika Litviňuková, Carlos Talavera-López, Henrike Maatz, Daniel Reichart, Catherine L. Worth, Eric L. Lindberg, Masatoshi Kanda, Krzysztof Polanski, Matthias Heinig, Michael Lee, Emily R. Nadelmann, Kenny Roberts, Liz Tuck, Eirini S. Fasouli, Daniel M. DeLaughter, Barbara McDonough, Hiroko Wakimoto, Joshua M. Gorham, Sara Samari, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, Giannino Patone, Joseph J. Boyle, Hongbo Zhang, Hao Zhang, Anissa Viveiros, Gavin Y. Oudit, Omer Ali Bayraktar, J. G. Seidman (), Christine E. Seidman (), Michela Noseda (), Norbert Hubner () and Sarah A. Teichmann ()
Additional contact information
Monika Litviňuková: Wellcome Genome Campus
Carlos Talavera-López: Wellcome Genome Campus
Henrike Maatz: Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
Daniel Reichart: Harvard Medical School
Catherine L. Worth: Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
Eric L. Lindberg: Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
Masatoshi Kanda: Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
Krzysztof Polanski: Wellcome Genome Campus
Matthias Heinig: Institute of Computational Biology (ICB), HMGU
Michael Lee: Imperial College London
Emily R. Nadelmann: Harvard Medical School
Kenny Roberts: Wellcome Genome Campus
Liz Tuck: Wellcome Genome Campus
Eirini S. Fasouli: Wellcome Genome Campus
Daniel M. DeLaughter: Harvard Medical School
Barbara McDonough: Harvard Medical School
Hiroko Wakimoto: Harvard Medical School
Joshua M. Gorham: Harvard Medical School
Sara Samari: Imperial College London
Krishnaa T. Mahbubani: University of Cambridge, NIHR Cambridge Biomedical Centre, Cambridge Biorepository for Translational Medicine
Kourosh Saeb-Parsy: University of Cambridge, NIHR Cambridge Biomedical Centre, Cambridge Biorepository for Translational Medicine
Giannino Patone: Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
Joseph J. Boyle: Imperial College London
Hongbo Zhang: Wellcome Genome Campus
Hao Zhang: University of Alberta
Anissa Viveiros: University of Alberta
Gavin Y. Oudit: University of Alberta
Omer Ali Bayraktar: Wellcome Genome Campus
J. G. Seidman: Harvard Medical School
Christine E. Seidman: Harvard Medical School
Michela Noseda: Imperial College London
Norbert Hubner: Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
Sarah A. Teichmann: Wellcome Genome Campus

Nature, 2020, vol. 588, issue 7838, 466-472

Abstract: Abstract Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavour. Here, using state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes, we characterize six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment, we identify cardiac-resident macrophages with inflammatory and protective transcriptional signatures. Furthermore, analyses of cell-to-cell interactions highlight different networks of macrophages, fibroblasts and cardiomyocytes between atria and ventricles that are distinct from those of skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a valuable reference for future studies.

Date: 2020
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DOI: 10.1038/s41586-020-2797-4

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