Coupling of hippocampal theta and ripples with pontogeniculooccipital waves

Juan F. Ramirez-Villegas, Michel Besserve, Yusuke Murayama, Henry C. Evrard, Axel Oeltermann and Nikos K. Logothetis ()
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Juan F. Ramirez-Villegas: Max Planck Institute for Biological Cybernetics
Michel Besserve: Max Planck Institute for Biological Cybernetics
Yusuke Murayama: Max Planck Institute for Biological Cybernetics
Henry C. Evrard: Max Planck Institute for Biological Cybernetics
Axel Oeltermann: Max Planck Institute for Biological Cybernetics
Nikos K. Logothetis: Max Planck Institute for Biological Cybernetics

Nature, 2021, vol. 589, issue 7840, 96-102

Abstract: Abstract The hippocampus has a major role in encoding and consolidating long-term memories, and undergoes plastic changes during sleep1. These changes require precise homeostatic control by subcortical neuromodulatory structures2. The underlying mechanisms of this phenomenon, however, remain unknown. Here, using multi-structure recordings in macaque monkeys, we show that the brainstem transiently modulates hippocampal network events through phasic pontine waves known as pontogeniculooccipital waves (PGO waves). Two physiologically distinct types of PGO wave appear to occur sequentially, selectively influencing high-frequency ripples and low-frequency theta events, respectively. The two types of PGO wave are associated with opposite hippocampal spike-field coupling, prompting periods of high neural synchrony of neural populations during periods of ripple and theta instances. The coupling between PGO waves and ripples, classically associated with distinct sleep stages, supports the notion that a global coordination mechanism of hippocampal sleep dynamics by cholinergic pontine transients may promote systems and synaptic memory consolidation as well as synaptic homeostasis.

Date: 2021
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DOI: 10.1038/s41586-020-2914-4

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