A network of transcriptional repressors modulates auxin responses

Jekaterina Truskina, Jingyi Han, Elina Chrysanthou, Carlos S. Galvan-Ampudia, Stéphanie Lainé, Géraldine Brunoud, Julien Macé, Simon Bellows, Jonathan Legrand, Anne-Maarit Bågman, Margot E. Smit, Ondřej Smetana, Arnaud Stigliani, Silvana Porco, Malcolm J. Bennett, Ari Pekka Mähönen, François Parcy, Etienne Farcot, Francois Roudier, Siobhan M. Brady, Anthony Bishopp () and Teva Vernoux ()
Additional contact information
Jekaterina Truskina: Université de Lyon, ENS de Lyon, UCB Lyon 1, CNRS, INRAE
Jingyi Han: University of Nottingham
Elina Chrysanthou: University of Nottingham
Carlos S. Galvan-Ampudia: Université de Lyon, ENS de Lyon, UCB Lyon 1, CNRS, INRAE
Stéphanie Lainé: Université de Lyon, ENS de Lyon, UCB Lyon 1, CNRS, INRAE
Géraldine Brunoud: Université de Lyon, ENS de Lyon, UCB Lyon 1, CNRS, INRAE
Julien Macé: Université de Lyon, ENS de Lyon, UCB Lyon 1, CNRS, INRAE
Simon Bellows: University of Nottingham
Jonathan Legrand: Université de Lyon, ENS de Lyon, UCB Lyon 1, CNRS, INRAE
Anne-Maarit Bågman: University of California Davis
Margot E. Smit: University of California Davis
Ondřej Smetana: University of Helsinki
Arnaud Stigliani: Université Grenoble Alpes, CNRS, CEA, INRAE, IRIG-DBSCI-LPCV
Silvana Porco: University of Nottingham
Malcolm J. Bennett: University of Nottingham
Ari Pekka Mähönen: University of Helsinki
François Parcy: Université Grenoble Alpes, CNRS, CEA, INRAE, IRIG-DBSCI-LPCV
Etienne Farcot: University of Nottingham
Francois Roudier: Université de Lyon, ENS de Lyon, UCB Lyon 1, CNRS, INRAE
Siobhan M. Brady: University of California Davis
Anthony Bishopp: University of Nottingham
Teva Vernoux: Université de Lyon, ENS de Lyon, UCB Lyon 1, CNRS, INRAE

Nature, 2021, vol. 589, issue 7840, 116-119

Abstract: Abstract The regulation of signalling capacity, combined with the spatiotemporal distribution of developmental signals themselves, is pivotal in setting developmental responses in both plants and animals1. The hormone auxin is a key signal for plant growth and development that acts through the AUXIN RESPONSE FACTOR (ARF) transcription factors2–4. A subset of these, the conserved class A ARFs5, are transcriptional activators of auxin-responsive target genes that are essential for regulating auxin signalling throughout the plant lifecycle2,3. Although class A ARFs have tissue-specific expression patterns, how their expression is regulated is unknown. Here we show, by investigating chromatin modifications and accessibility, that loci encoding these proteins are constitutively open for transcription. Through yeast one-hybrid screening, we identify the transcriptional regulators of the genes encoding class A ARFs from Arabidopsis thaliana and demonstrate that each gene is controlled by specific sets of transcriptional regulators. Transient transformation assays and expression analyses in mutants reveal that, in planta, the majority of these regulators repress the transcription of genes encoding class A ARFs. These observations support a scenario in which the default configuration of open chromatin enables a network of transcriptional repressors to regulate expression levels of class A ARF proteins and modulate auxin signalling output throughout development.

Date: 2021
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DOI: 10.1038/s41586-020-2940-2

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