Cortex-dependent corrections as the tongue reaches for and misses targets

Tejapratap Bollu, Brendan S. Ito, Samuel C. Whitehead, Brian Kardon, James Redd, Mei Hong Liu and Jesse H. Goldberg ()
Additional contact information
Tejapratap Bollu: Cornell University
Brendan S. Ito: Cornell University
Samuel C. Whitehead: Cornell University
Brian Kardon: Cornell University
James Redd: Cornell University
Mei Hong Liu: Cornell University
Jesse H. Goldberg: Cornell University

Nature, 2021, vol. 594, issue 7861, 82-87

Abstract: Abstract Precise tongue control is necessary for drinking, eating and vocalizing1–3. However, because tongue movements are fast and difficult to resolve, neural control of lingual kinematics remains poorly understood. Here we combine kilohertz-frame-rate imaging and a deep-learning-based neural network to resolve 3D tongue kinematics in mice drinking from a water spout. Successful licks required corrective submovements that—similar to online corrections during primate reaches4–11—occurred after the tongue missed unseen, distant or displaced targets. Photoinhibition of anterolateral motor cortex impaired corrections, which resulted in hypometric licks that missed the spout. Neural activity in anterolateral motor cortex reflected upcoming, ongoing and past corrective submovements, as well as errors in predicted spout contact. Although less than a tenth of a second in duration, a single mouse lick exhibits the hallmarks of online motor control associated with a primate reach, including cortex-dependent corrections after misses.

Date: 2021
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41586-021-03561-9 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:594:y:2021:i:7861:d:10.1038_s41586-021-03561-9

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/s41586-021-03561-9

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().