A roadmap for the Human Developmental Cell Atlas

Muzlifah Haniffa (), Deanne Taylor, Sten Linnarsson, Bruce J. Aronow, Gary D. Bader, Roger A. Barker, Pablo G. Camara, J. Gray Camp, Alain Chédotal, Andrew Copp, Heather C. Etchevers, Paolo Giacobini, Berthold Göttgens, Guoji Guo, Ania Hupalowska, Kylie R. James, Emily Kirby, Arnold Kriegstein, Joakim Lundeberg, John C. Marioni, Kerstin B. Meyer, Kathy K. Niakan, Mats Nilsson, Bayanne Olabi, Dana Pe’er, Aviv Regev, Jennifer Rood, Orit Rozenblatt-Rosen, Rahul Satija, Sarah A. Teichmann, Barbara Treutlein, Roser Vento-Tormo and Simone Webb
Additional contact information
Muzlifah Haniffa: Newcastle University
Deanne Taylor: The Children’s Hospital of Philadelphia
Sten Linnarsson: Karolinska Institutet
Bruce J. Aronow: Cincinnati Children’s Hospital Medical Centre
Gary D. Bader: University of Toronto
Roger A. Barker: University of Cambridge
Pablo G. Camara: University of Pennsylvania Perelman School of Medicine
J. Gray Camp: University of Basel
Alain Chédotal: INSERM, CNRS, Institut de la Vision, Sorbonne Université
Andrew Copp: UCL Great Ormond Street Institute of Child Health
Heather C. Etchevers: MMG, INSERM, U1251, Aix Marseille Université
Paolo Giacobini: Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm, CHU Lille, Lille Neuroscience and Cognition, UMR-S 1172, Université Lille
Berthold Göttgens: University of Cambridge
Guoji Guo: Zhejiang University School of Medicine
Ania Hupalowska: Klarman Cell Observatory, Broad Institute of Harvard and MIT
Kylie R. James: Wellcome Sanger Institute
Emily Kirby: McGill University
Arnold Kriegstein: University of California San Francisco (UCSF)
Joakim Lundeberg: Science for Life Laboratory, KTH Royal Institute of Technology
John C. Marioni: University of Cambridge
Kerstin B. Meyer: Wellcome Sanger Institute
Kathy K. Niakan: Francis Crick Institute
Mats Nilsson: Stockholm University
Bayanne Olabi: Newcastle University
Dana Pe’er: Memorial Sloan Kettering Cancer Center
Aviv Regev: Klarman Cell Observatory, Broad Institute of Harvard and MIT
Jennifer Rood: Klarman Cell Observatory, Broad Institute of Harvard and MIT
Orit Rozenblatt-Rosen: Klarman Cell Observatory, Broad Institute of Harvard and MIT
Rahul Satija: New York University
Sarah A. Teichmann: Wellcome Sanger Institute
Barbara Treutlein: Eidgenössische Technische Hochschule (ETH) Zurich
Roser Vento-Tormo: Wellcome Sanger Institute
Simone Webb: Newcastle University

Nature, 2021, vol. 597, issue 7875, 196-205

Abstract: Abstract The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human Cell Atlas, aims to create a comprehensive reference map of cells during development. This will be critical to understanding normal organogenesis, the effect of mutations, environmental factors and infectious agents on human development, congenital and childhood disorders, and the cellular basis of ageing, cancer and regenerative medicine. Here we outline the HDCA initiative and the challenges of mapping and modelling human development using state-of-the-art technologies to create a reference atlas across gestation. Similar to the Human Genome Project, the HDCA will integrate the output from a growing community of scientists who are mapping human development into a unified atlas. We describe the early milestones that have been achieved and the use of human stem-cell-derived cultures, organoids and animal models to inform the HDCA, especially for prenatal tissues that are hard to acquire. Finally, we provide a roadmap towards a complete atlas of human development.

Date: 2021
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DOI: 10.1038/s41586-021-03620-1

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