Cellular anatomy of the mouse primary motor cortex

Rodrigo Muñoz-Castañeda, Brian Zingg, Katherine S. Matho, Xiaoyin Chen, Quanxin Wang, Nicholas N. Foster, Anan Li, Arun Narasimhan, Karla E. Hirokawa, Bingxing Huo, Samik Bannerjee, Laura Korobkova, Chris Sin Park, Young-Gyun Park, Michael S. Bienkowski, Uree Chon, Diek W. Wheeler, Xiangning Li, Yun Wang, Maitham Naeemi, Peng Xie, Lijuan Liu, Kathleen Kelly, Xu An, Sarojini M. Attili, Ian Bowman, Anastasiia Bludova, Ali Cetin, Liya Ding, Rhonda Drewes, Florence D’Orazi, Corey Elowsky, Stephan Fischer, William Galbavy, Lei Gao, Jesse Gillis, Peter A. Groblewski, Lin Gou, Joel D. Hahn, Joshua T. Hatfield, Houri Hintiryan, Junxiang Jason Huang, Hideki Kondo, Xiuli Kuang, Philip Lesnar, Xu Li, Yaoyao Li, Mengkuan Lin, Darrick Lo, Judith Mizrachi, Stephanie Mok, Philip R. Nicovich, Ramesh Palaniswamy, Jason Palmer, Xiaoli Qi, Elise Shen, Yu-Chi Sun, Huizhong W. Tao, Wayne Wakemen, Yimin Wang, Shenqin Yao, Jing Yuan, Huiqing Zhan, Muye Zhu, Lydia Ng, Li I. Zhang, Byung Kook Lim, Michael Hawrylycz, Hui Gong, James C. Gee, Yongsoo Kim, Kwanghun Chung, X. William Yang, Hanchuan Peng, Qingming Luo, Partha P. Mitra, Anthony M. Zador, Hongkui Zeng, Giorgio A. Ascoli (), Z. Josh Huang (), Pavel Osten (), Julie A. Harris () and Hong-Wei Dong ()
Additional contact information
Rodrigo Muñoz-Castañeda: Cold Spring Harbor Laboratory
Brian Zingg: University of California Los Angeles
Katherine S. Matho: Cold Spring Harbor Laboratory
Xiaoyin Chen: Cold Spring Harbor Laboratory
Quanxin Wang: Allen Institute for Brain Science
Nicholas N. Foster: University of California Los Angeles
Anan Li: Huazhong University of Science and Technology
Arun Narasimhan: Cold Spring Harbor Laboratory
Karla E. Hirokawa: Allen Institute for Brain Science
Bingxing Huo: Cold Spring Harbor Laboratory
Samik Bannerjee: Cold Spring Harbor Laboratory
Laura Korobkova: University of Southern California
Chris Sin Park: David Geffen School of Medicine at UCLA
Young-Gyun Park: Massachusetts Institute of Technology (MIT)
Michael S. Bienkowski: University of Southern California
Uree Chon: Penn State University
Diek W. Wheeler: George Mason University
Xiangning Li: Huazhong University of Science and Technology
Yun Wang: Allen Institute for Brain Science
Maitham Naeemi: Allen Institute for Brain Science
Peng Xie: Southeast University
Lijuan Liu: Southeast University
Kathleen Kelly: Cold Spring Harbor Laboratory
Xu An: Cold Spring Harbor Laboratory
Sarojini M. Attili: George Mason University
Ian Bowman: University of California Los Angeles
Anastasiia Bludova: Cold Spring Harbor Laboratory
Ali Cetin: Allen Institute for Brain Science
Liya Ding: Southeast University
Rhonda Drewes: Cold Spring Harbor Laboratory
Florence D’Orazi: Allen Institute for Brain Science
Corey Elowsky: Cold Spring Harbor Laboratory
Stephan Fischer: Cold Spring Harbor Laboratory
William Galbavy: Cold Spring Harbor Laboratory
Lei Gao: University of California Los Angeles
Jesse Gillis: Cold Spring Harbor Laboratory
Peter A. Groblewski: Allen Institute for Brain Science
Lin Gou: University of California Los Angeles
Joel D. Hahn: University of Southern California
Joshua T. Hatfield: Cold Spring Harbor Laboratory
Houri Hintiryan: University of California Los Angeles
Junxiang Jason Huang: University of Southern California
Hideki Kondo: Cold Spring Harbor Laboratory
Xiuli Kuang: Wenzhou Medical University
Philip Lesnar: Allen Institute for Brain Science
Xu Li: Cold Spring Harbor Laboratory
Yaoyao Li: Wenzhou Medical University
Mengkuan Lin: Cold Spring Harbor Laboratory
Darrick Lo: University of California Los Angeles
Judith Mizrachi: Cold Spring Harbor Laboratory
Stephanie Mok: Allen Institute for Brain Science
Philip R. Nicovich: Allen Institute for Brain Science
Ramesh Palaniswamy: Cold Spring Harbor Laboratory
Jason Palmer: Cold Spring Harbor Laboratory
Xiaoli Qi: Cold Spring Harbor Laboratory
Elise Shen: Allen Institute for Brain Science
Yu-Chi Sun: Cold Spring Harbor Laboratory
Huizhong W. Tao: University of Southern California
Wayne Wakemen: Allen Institute for Brain Science
Yimin Wang: Southeast University
Shenqin Yao: Allen Institute for Brain Science
Jing Yuan: Huazhong University of Science and Technology
Huiqing Zhan: Cold Spring Harbor Laboratory
Muye Zhu: University of California Los Angeles
Lydia Ng: Allen Institute for Brain Science
Li I. Zhang: University of Southern California
Byung Kook Lim: HUST–Suzhou Institute for Brainsmatics, JITRI
Michael Hawrylycz: Allen Institute for Brain Science
Hui Gong: Huazhong University of Science and Technology
James C. Gee: University of Pennsylvania
Yongsoo Kim: Penn State University
Kwanghun Chung: Massachusetts Institute of Technology (MIT)
X. William Yang: David Geffen School of Medicine at UCLA
Hanchuan Peng: Southeast University
Qingming Luo: Huazhong University of Science and Technology
Partha P. Mitra: Cold Spring Harbor Laboratory
Anthony M. Zador: Cold Spring Harbor Laboratory
Hongkui Zeng: Allen Institute for Brain Science
Giorgio A. Ascoli: George Mason University
Z. Josh Huang: Cold Spring Harbor Laboratory
Pavel Osten: Cold Spring Harbor Laboratory
Julie A. Harris: Allen Institute for Brain Science
Hong-Wei Dong: University of California Los Angeles

Nature, 2021, vol. 598, issue 7879, 159-166

Abstract: Abstract An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integrated and interpreted1. Here, as part of the collaborative Brain Initiative Cell Census Network (BICCN), we derive a comprehensive cell type-based anatomical description of one exemplar brain structure, the mouse primary motor cortex, upper limb area (MOp-ul). Using genetic and viral labelling, barcoded anatomy resolved by sequencing, single-neuron reconstruction, whole-brain imaging and cloud-based neuroinformatics tools, we delineated the MOp-ul in 3D and refined its sublaminar organization. We defined around two dozen projection neuron types in the MOp-ul and derived an input–output wiring diagram, which will facilitate future analyses of motor control circuitry across molecular, cellular and system levels. This work provides a roadmap towards a comprehensive cellular-resolution description of mammalian brain architecture.

Date: 2021
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DOI: 10.1038/s41586-021-03970-w

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