The EDS1–PAD4–ADR1 node mediates Arabidopsis pattern-triggered immunity

Rory N. Pruitt, Federica Locci, Friederike Wanke, Lisha Zhang, Svenja C. Saile, Anna Joe, Darya Karelina, Chenlei Hua, Katja Fröhlich, Wei-Lin Wan, Meijuan Hu, Shaofei Rao, Sara C. Stolze, Anne Harzen, Andrea A. Gust, Klaus Harter, Matthieu H. A. J. Joosten, Bart P. H. J. Thomma, Jian-Min Zhou, Jeffery L. Dangl, Detlef Weigel, Hirofumi Nakagami, Claudia Oecking, Farid El Kasmi, Jane E. Parker () and Thorsten Nürnberger ()
Additional contact information
Rory N. Pruitt: University of Tübingen
Federica Locci: Max Planck Institute for Plant Breeding Research
Friederike Wanke: University of Tübingen
Lisha Zhang: University of Tübingen
Svenja C. Saile: University of Tübingen
Anna Joe: University of Tübingen
Darya Karelina: Max Planck Institute for Developmental Biology
Chenlei Hua: University of Tübingen
Katja Fröhlich: University of Tübingen
Wei-Lin Wan: University of Tübingen
Meijuan Hu: Chinese Academy of Sciences
Shaofei Rao: Chinese Academy of Sciences
Sara C. Stolze: Max Planck Institute for Plant Breeding Research
Anne Harzen: Max Planck Institute for Plant Breeding Research
Andrea A. Gust: University of Tübingen
Klaus Harter: University of Tübingen
Matthieu H. A. J. Joosten: Wageningen University
Bart P. H. J. Thomma: Wageningen University
Jian-Min Zhou: Chinese Academy of Sciences
Jeffery L. Dangl: University of North Carolina at Chapel Hill
Detlef Weigel: Max Planck Institute for Developmental Biology
Hirofumi Nakagami: Max Planck Institute for Plant Breeding Research
Claudia Oecking: University of Tübingen
Farid El Kasmi: University of Tübingen
Jane E. Parker: Max Planck Institute for Plant Breeding Research
Thorsten Nürnberger: University of Tübingen

Nature, 2021, vol. 598, issue 7881, 495-499

Abstract: Abstract Plants deploy cell-surface and intracellular leucine rich-repeat domain (LRR) immune receptors to detect pathogens1. LRR receptor kinases and LRR receptor proteins at the plasma membrane recognize microorganism-derived molecules to elicit pattern-triggered immunity (PTI), whereas nucleotide-binding LRR proteins detect microbial effectors inside cells to confer effector-triggered immunity (ETI). Although PTI and ETI are initiated in different host cell compartments, they rely on the transcriptional activation of similar sets of genes2, suggesting pathway convergence upstream of nuclear events. Here we report that PTI triggered by the Arabidopsis LRR receptor protein RLP23 requires signalling-competent dimers of the lipase-like proteins EDS1 and PAD4, and of ADR1 family helper nucleotide-binding LRRs, which are all components of ETI. The cell-surface LRR receptor kinase SOBIR1 links RLP23 with EDS1, PAD4 and ADR1 proteins, suggesting the formation of supramolecular complexes containing PTI receptors and transducers at the inner side of the plasma membrane. We detected similar evolutionary patterns in LRR receptor protein and nucleotide-binding LRR genes across Arabidopsis accessions; overall higher levels of variation in LRR receptor proteins than in LRR receptor kinases are consistent with distinct roles of these two receptor families in plant immunity. We propose that the EDS1–PAD4–ADR1 node is a convergence point for defence signalling cascades, activated by both surface-resident and intracellular LRR receptors, in conferring pathogen immunity.

Date: 2021
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DOI: 10.1038/s41586-021-03829-0

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