Activation of TIR signalling boosts pattern-triggered immunity

Hainan Tian, Zhongshou Wu, Siyu Chen, Kevin Ao, Weijie Huang, Hoda Yaghmaiean, Tongjun Sun, Fang Xu, Yanjun Zhang, Shucai Wang, Xin Li () and Yuelin Zhang ()
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Hainan Tian: University of British Columbia
Zhongshou Wu: University of British Columbia
Siyu Chen: University of British Columbia
Kevin Ao: University of British Columbia
Weijie Huang: University of British Columbia
Hoda Yaghmaiean: University of British Columbia
Tongjun Sun: University of British Columbia
Fang Xu: University of British Columbia
Yanjun Zhang: University of British Columbia
Shucai Wang: Linyi University
Xin Li: University of British Columbia
Yuelin Zhang: University of British Columbia

Nature, 2021, vol. 598, issue 7881, 500-503

Abstract: Abstract Plant immune responses are mainly activated by two types of receptor. Pattern recognition receptors localized on the plasma membrane perceive extracellular microbial features, and nucleotide-binding leucine-rich repeat receptors (NLRs) recognize intracellular effector proteins from pathogens1. NLRs possessing amino-terminal Toll/interleukin-1 receptor (TIR) domains activate defence responses via the NADase activity of the TIR domain2,3. Here we report that activation of TIR signalling has a key role in pattern-triggered immunity (PTI) mediated by pattern recognition receptors. TIR signalling mutants exhibit attenuated PTI responses and decreased resistance against pathogens. Consistently, PTI is compromised in plants with reduced NLR levels. Treatment with the PTI elicitor flg22 or nlp20 rapidly induces many genes encoding TIR-domain-containing proteins, which is likely to be responsible for activating TIR signalling during PTI. Overall, our study reveals that activation of TIR signalling is an important mechanism for boosting plant defence during PTI.

Date: 2021
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DOI: 10.1038/s41586-021-03987-1

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