Single-cell delineation of lineage and genetic identity in the mouse brain

Rachel C. Bandler, Ilaria Vitali, Ryan N. Delgado, May C. Ho, Elena Dvoretskova, Josue S. Ibarra Molinas, Paul W. Frazel, Maesoumeh Mohammadkhani, Robert Machold, Sophia Maedler, Shane A. Liddelow, Tomasz J. Nowakowski, Gord Fishell and Christian Mayer ()
Additional contact information
Rachel C. Bandler: Max Planck Institute of Neurobiology
Ilaria Vitali: Max Planck Institute of Neurobiology
Ryan N. Delgado: University of California
May C. Ho: Max Planck Institute of Neurobiology
Elena Dvoretskova: Max Planck Institute of Neurobiology
Josue S. Ibarra Molinas: Max Planck Institute of Neurobiology
Paul W. Frazel: Langone Medical Center
Maesoumeh Mohammadkhani: Langone Medical Center
Robert Machold: Langone Medical Center
Sophia Maedler: Max Planck Institute of Biochemistry
Shane A. Liddelow: Langone Medical Center
Tomasz J. Nowakowski: University of California
Gord Fishell: Stanley Center for Psychiatric Research
Christian Mayer: Max Planck Institute of Neurobiology

Nature, 2022, vol. 601, issue 7893, 404-409

Abstract: Abstract During neurogenesis, mitotic progenitor cells lining the ventricles of the embryonic mouse brain undergo their final rounds of cell division, giving rise to a wide spectrum of postmitotic neurons and glia1,2. The link between developmental lineage and cell-type diversity remains an open question. Here we used massively parallel tagging of progenitors to track clonal relationships and transcriptomic signatures during mouse forebrain development. We quantified clonal divergence and convergence across all major cell classes postnatally, and found diverse types of GABAergic neuron that share a common lineage. Divergence of GABAergic clones occurred during embryogenesis upon cell-cycle exit, suggesting that differentiation into subtypes is initiated as a lineage-dependent process at the progenitor cell level.

Date: 2022
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DOI: 10.1038/s41586-021-04237-0

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